DERIVADOS DE BENZOXAZINONA, SU PREPARACION Y USO
Un compuesto de **fórmula*o una de sus sales farmacéuticamente aceptable, en la que Ar es fenilo, naftilo, un grupo heteroaromático monocíclico o un grupo heteroaromático bicíclico, estando dicho grupo Ar opcionalmente sustituido con 1 - 4 sustituyentes, que pueden ser iguales o diferentes, y que se...
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| creator | STEMP, GEOFFREY GLAXOSMITHKLINE PHARMA RAMI, HARSHAD KANTILAL SMITHKLINE BEECHAM PHARMA JOHNSON, CHRISTOPHER N. GLAXOSMITHKLINE PHARMA THEWLIS, KEVIN GLAXOSMITHKLINE PHARMACEUTICALS VONG, ANTONIO, KUOK K. SMITHKLINE BEECHAM PHARMA THOMPSON, MERVYN GLAXOSMITHKLINE PHARMACEUTICALS |
| description | Un compuesto de **fórmula*o una de sus sales farmacéuticamente aceptable, en la que Ar es fenilo, naftilo, un grupo heteroaromático monocíclico o un grupo heteroaromático bicíclico, estando dicho grupo Ar opcionalmente sustituido con 1 - 4 sustituyentes, que pueden ser iguales o diferentes, y que se seleccionan del grupo que consta de: halógeno, hidroxi, ciano, nitro, trifluorometilo, trifluorometoxi, alquilo C1-6, trifluorometanosulfoniloxi, pentafluoroetilo, alcoxi C1-6, aril-alcoxi(C1-6), alquil(C1-6)-tio, alcoxi(C1-6)-alquilo- (C1-6), cicloalquil(C3-7)-alcoxi(C1-6), alcanoilo C1-6, alcoxi(C1-6)-carbonilo, alquil(C1-6)-sulfonilo, alquil(C1-6)-sulfinilo, alquil(C1-6)-sulfoniloxi, alquil(C1-6)-sulfonil-alquilo(C1-6), arilsulfonilo, arilsulfoniloxi, arilsulfonil-alquilo(C1-6), alquil(C1-6)-sulfonamido, alquil(C1-6)-amido, alquil(C1-6)-sulfonamido-alquilo(C1-6), alquil(C1-6)-amido-alquilo(C1-6), arilsulfonamido, arilcarboxamido, arilsulfonamido-alquilo(C1-6), arilcarboxamido-alquilo(C1-6), aroilo, aroil-alquilo(C1-6), aril-alcanoilo(C1-6), un grupo R3OCO(CH2)s, R3CON(R4)(CH2)s, R3R4NCO(CH2)s o R3R4NSO2(CH2)s, donde cada uno de R3 y R4 representan independientemente un átomo de hidrógeno o alquilo C1-4, o R3 y R4 forman parte de un anillo de azacicloalcano C3-6 o (2-oxo)azacicloalcano C3-6 y s representa cero o un número entero de 1 a 4.
The present invention relates to novel compounds of formula (I) or a pharmaceutically acceptable salt thereof, wherein Ar is phenyl, naphthyl, a monocyclic heteroaromatic group or a bicyclic heteroaromatic group, said Ar group being optionally substituted by 1-4 substituents, which may be the same or different, and which are selected from the group consisting of: halogen, hydroxy, cyano, nitro, trifluoromethyl, trifluoromethoxy, C1-6alkyl, trifluoromethanesulfonyloxy, pentafluoroethyl, C1-6alkoxy, arylC1-6alkoxy, C1-6alkylthio, C1-6alkoxyC1-6-alkyl, C3-7cycloalkylC1-6alkoxy, C1-6alkanoyl, C1-6alkoxycarbonyl, C1-6alkylsulfonyl, C1-6alkylsulfinyl, C1-6alkylsulfonyloxy, C1-6alkylsulfonylC1-6alkyl, arylsulfonyl, arylsulfonyloxy, arylsulfonylC1-6alkyl, C1-6alkylsulfonamido, C1-6alkylamido, C1-6alkylsulfonamidoC1-6alkyl, C1-6alkylamidoC1-6alkyl, arylsulfonamido, arylcarboxamido, alkylsulfonamidoC1-6alkyl, arylcarboxamidoC1-6alkyl, aroyl, arolC1-6alkyl, arylC1-6alkanoyl, a group R OCO(CH2)s, R CON(R )(CH2)s, R R NCO(CH2)s or R R NSO2(CH2) where each of R and R independently represents a hydrogen atom or C1-4alkyl or R and R form pa |
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| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_ES2280417TT3</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>ES2280417TT3</sourcerecordid><originalsourceid>FETCH-epo_espacenet_ES2280417TT33</originalsourceid><addsrcrecordid>eNrjZDBwcQ3yDHN08Q9WcHFVcHL1i_KPcIzy9PP3c9RRCA5VCAhyDXAMcnT29PdTiFQIDfbnYWBNS8wpTuWF0twMim6uIc4euqkF-fGpxQWJyal5qSXxrsFGRhYGJobmISHGxsSoAQA1eCax</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>DERIVADOS DE BENZOXAZINONA, SU PREPARACION Y USO</title><source>esp@cenet</source><creator>STEMP, GEOFFREY GLAXOSMITHKLINE PHARMA ; RAMI, HARSHAD KANTILAL SMITHKLINE BEECHAM PHARMA ; JOHNSON, CHRISTOPHER N. GLAXOSMITHKLINE PHARMA ; THEWLIS, KEVIN GLAXOSMITHKLINE PHARMACEUTICALS ; VONG, ANTONIO, KUOK K. SMITHKLINE BEECHAM PHARMA ; THOMPSON, MERVYN GLAXOSMITHKLINE PHARMACEUTICALS</creator><creatorcontrib>STEMP, GEOFFREY GLAXOSMITHKLINE PHARMA ; RAMI, HARSHAD KANTILAL SMITHKLINE BEECHAM PHARMA ; JOHNSON, CHRISTOPHER N. GLAXOSMITHKLINE PHARMA ; THEWLIS, KEVIN GLAXOSMITHKLINE PHARMACEUTICALS ; VONG, ANTONIO, KUOK K. SMITHKLINE BEECHAM PHARMA ; THOMPSON, MERVYN GLAXOSMITHKLINE PHARMACEUTICALS</creatorcontrib><description>Un compuesto de **fórmula*o una de sus sales farmacéuticamente aceptable, en la que Ar es fenilo, naftilo, un grupo heteroaromático monocíclico o un grupo heteroaromático bicíclico, estando dicho grupo Ar opcionalmente sustituido con 1 - 4 sustituyentes, que pueden ser iguales o diferentes, y que se seleccionan del grupo que consta de: halógeno, hidroxi, ciano, nitro, trifluorometilo, trifluorometoxi, alquilo C1-6, trifluorometanosulfoniloxi, pentafluoroetilo, alcoxi C1-6, aril-alcoxi(C1-6), alquil(C1-6)-tio, alcoxi(C1-6)-alquilo- (C1-6), cicloalquil(C3-7)-alcoxi(C1-6), alcanoilo C1-6, alcoxi(C1-6)-carbonilo, alquil(C1-6)-sulfonilo, alquil(C1-6)-sulfinilo, alquil(C1-6)-sulfoniloxi, alquil(C1-6)-sulfonil-alquilo(C1-6), arilsulfonilo, arilsulfoniloxi, arilsulfonil-alquilo(C1-6), alquil(C1-6)-sulfonamido, alquil(C1-6)-amido, alquil(C1-6)-sulfonamido-alquilo(C1-6), alquil(C1-6)-amido-alquilo(C1-6), arilsulfonamido, arilcarboxamido, arilsulfonamido-alquilo(C1-6), arilcarboxamido-alquilo(C1-6), aroilo, aroil-alquilo(C1-6), aril-alcanoilo(C1-6), un grupo R3OCO(CH2)s, R3CON(R4)(CH2)s, R3R4NCO(CH2)s o R3R4NSO2(CH2)s, donde cada uno de R3 y R4 representan independientemente un átomo de hidrógeno o alquilo C1-4, o R3 y R4 forman parte de un anillo de azacicloalcano C3-6 o (2-oxo)azacicloalcano C3-6 y s representa cero o un número entero de 1 a 4.
The present invention relates to novel compounds of formula (I) or a pharmaceutically acceptable salt thereof, wherein Ar is phenyl, naphthyl, a monocyclic heteroaromatic group or a bicyclic heteroaromatic group, said Ar group being optionally substituted by 1-4 substituents, which may be the same or different, and which are selected from the group consisting of: halogen, hydroxy, cyano, nitro, trifluoromethyl, trifluoromethoxy, C1-6alkyl, trifluoromethanesulfonyloxy, pentafluoroethyl, C1-6alkoxy, arylC1-6alkoxy, C1-6alkylthio, C1-6alkoxyC1-6-alkyl, C3-7cycloalkylC1-6alkoxy, C1-6alkanoyl, C1-6alkoxycarbonyl, C1-6alkylsulfonyl, C1-6alkylsulfinyl, C1-6alkylsulfonyloxy, C1-6alkylsulfonylC1-6alkyl, arylsulfonyl, arylsulfonyloxy, arylsulfonylC1-6alkyl, C1-6alkylsulfonamido, C1-6alkylamido, C1-6alkylsulfonamidoC1-6alkyl, C1-6alkylamidoC1-6alkyl, arylsulfonamido, arylcarboxamido, alkylsulfonamidoC1-6alkyl, arylcarboxamidoC1-6alkyl, aroyl, arolC1-6alkyl, arylC1-6alkanoyl, a group R OCO(CH2)s, R CON(R )(CH2)s, R R NCO(CH2)s or R R NSO2(CH2) where each of R and R independently represents a hydrogen atom or C1-4alkyl or R and R form part of a C3-6azacyloalkane or C3-6(2-oxo)azacycloalkane ring and s represents zero or an integer from 1 to 4, and a group Ar Z, wherein Z represents a single bond, O, S or CH2 and Ar represents a phenyl or a monocyclic heteroaromatic group, said Ar group being optionally substituted by 1-3 substituents, which may be the same or different, and which are selected from the group consisting of a halogen, hydroxy, cyano, trifluoromethyl, C1-6alkyl, C1-6alkoxy or C1-6alkanoyl; when Ar is a phenyl or a monocyclic heteroaromatic group, substitutents positioned ortho to one another may be linked to form a 5- or 6-membered ring; R is hydrogen, C1-6alkyl, C3-6alkenyl, C3-6alkynyl or arylC1-6alkyl; R is halogen, C1-6alkyl, cyano, CF3, C1-6alkanoyl, C1-6alkoxy or hydroxy; X is CH or N; Y is a single bond, O, or C-O; p is 0, 1 or 2; r is 0, 1, 2 or 3; m is 2, 3 or 4; n and q are independently 1 or 2. Processes for preparing the compounds, pharmaceutical compositions containing them and their use as medicaments for various CNS disorders, including deression and/or anxiety, are also disclosed.</description><language>spa</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2007</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20070916&DB=EPODOC&CC=ES&NR=2280417T3$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,777,882,25545,76296</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20070916&DB=EPODOC&CC=ES&NR=2280417T3$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>STEMP, GEOFFREY GLAXOSMITHKLINE PHARMA</creatorcontrib><creatorcontrib>RAMI, HARSHAD KANTILAL SMITHKLINE BEECHAM PHARMA</creatorcontrib><creatorcontrib>JOHNSON, CHRISTOPHER N. GLAXOSMITHKLINE PHARMA</creatorcontrib><creatorcontrib>THEWLIS, KEVIN GLAXOSMITHKLINE PHARMACEUTICALS</creatorcontrib><creatorcontrib>VONG, ANTONIO, KUOK K. SMITHKLINE BEECHAM PHARMA</creatorcontrib><creatorcontrib>THOMPSON, MERVYN GLAXOSMITHKLINE PHARMACEUTICALS</creatorcontrib><title>DERIVADOS DE BENZOXAZINONA, SU PREPARACION Y USO</title><description>Un compuesto de **fórmula*o una de sus sales farmacéuticamente aceptable, en la que Ar es fenilo, naftilo, un grupo heteroaromático monocíclico o un grupo heteroaromático bicíclico, estando dicho grupo Ar opcionalmente sustituido con 1 - 4 sustituyentes, que pueden ser iguales o diferentes, y que se seleccionan del grupo que consta de: halógeno, hidroxi, ciano, nitro, trifluorometilo, trifluorometoxi, alquilo C1-6, trifluorometanosulfoniloxi, pentafluoroetilo, alcoxi C1-6, aril-alcoxi(C1-6), alquil(C1-6)-tio, alcoxi(C1-6)-alquilo- (C1-6), cicloalquil(C3-7)-alcoxi(C1-6), alcanoilo C1-6, alcoxi(C1-6)-carbonilo, alquil(C1-6)-sulfonilo, alquil(C1-6)-sulfinilo, alquil(C1-6)-sulfoniloxi, alquil(C1-6)-sulfonil-alquilo(C1-6), arilsulfonilo, arilsulfoniloxi, arilsulfonil-alquilo(C1-6), alquil(C1-6)-sulfonamido, alquil(C1-6)-amido, alquil(C1-6)-sulfonamido-alquilo(C1-6), alquil(C1-6)-amido-alquilo(C1-6), arilsulfonamido, arilcarboxamido, arilsulfonamido-alquilo(C1-6), arilcarboxamido-alquilo(C1-6), aroilo, aroil-alquilo(C1-6), aril-alcanoilo(C1-6), un grupo R3OCO(CH2)s, R3CON(R4)(CH2)s, R3R4NCO(CH2)s o R3R4NSO2(CH2)s, donde cada uno de R3 y R4 representan independientemente un átomo de hidrógeno o alquilo C1-4, o R3 y R4 forman parte de un anillo de azacicloalcano C3-6 o (2-oxo)azacicloalcano C3-6 y s representa cero o un número entero de 1 a 4.
The present invention relates to novel compounds of formula (I) or a pharmaceutically acceptable salt thereof, wherein Ar is phenyl, naphthyl, a monocyclic heteroaromatic group or a bicyclic heteroaromatic group, said Ar group being optionally substituted by 1-4 substituents, which may be the same or different, and which are selected from the group consisting of: halogen, hydroxy, cyano, nitro, trifluoromethyl, trifluoromethoxy, C1-6alkyl, trifluoromethanesulfonyloxy, pentafluoroethyl, C1-6alkoxy, arylC1-6alkoxy, C1-6alkylthio, C1-6alkoxyC1-6-alkyl, C3-7cycloalkylC1-6alkoxy, C1-6alkanoyl, C1-6alkoxycarbonyl, C1-6alkylsulfonyl, C1-6alkylsulfinyl, C1-6alkylsulfonyloxy, C1-6alkylsulfonylC1-6alkyl, arylsulfonyl, arylsulfonyloxy, arylsulfonylC1-6alkyl, C1-6alkylsulfonamido, C1-6alkylamido, C1-6alkylsulfonamidoC1-6alkyl, C1-6alkylamidoC1-6alkyl, arylsulfonamido, arylcarboxamido, alkylsulfonamidoC1-6alkyl, arylcarboxamidoC1-6alkyl, aroyl, arolC1-6alkyl, arylC1-6alkanoyl, a group R OCO(CH2)s, R CON(R )(CH2)s, R R NCO(CH2)s or R R NSO2(CH2) where each of R and R independently represents a hydrogen atom or C1-4alkyl or R and R form part of a C3-6azacyloalkane or C3-6(2-oxo)azacycloalkane ring and s represents zero or an integer from 1 to 4, and a group Ar Z, wherein Z represents a single bond, O, S or CH2 and Ar represents a phenyl or a monocyclic heteroaromatic group, said Ar group being optionally substituted by 1-3 substituents, which may be the same or different, and which are selected from the group consisting of a halogen, hydroxy, cyano, trifluoromethyl, C1-6alkyl, C1-6alkoxy or C1-6alkanoyl; when Ar is a phenyl or a monocyclic heteroaromatic group, substitutents positioned ortho to one another may be linked to form a 5- or 6-membered ring; R is hydrogen, C1-6alkyl, C3-6alkenyl, C3-6alkynyl or arylC1-6alkyl; R is halogen, C1-6alkyl, cyano, CF3, C1-6alkanoyl, C1-6alkoxy or hydroxy; X is CH or N; Y is a single bond, O, or C-O; p is 0, 1 or 2; r is 0, 1, 2 or 3; m is 2, 3 or 4; n and q are independently 1 or 2. Processes for preparing the compounds, pharmaceutical compositions containing them and their use as medicaments for various CNS disorders, including deression and/or anxiety, are also disclosed.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2007</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZDBwcQ3yDHN08Q9WcHFVcHL1i_KPcIzy9PP3c9RRCA5VCAhyDXAMcnT29PdTiFQIDfbnYWBNS8wpTuWF0twMim6uIc4euqkF-fGpxQWJyal5qSXxrsFGRhYGJobmISHGxsSoAQA1eCax</recordid><startdate>20070916</startdate><enddate>20070916</enddate><creator>STEMP, GEOFFREY GLAXOSMITHKLINE PHARMA</creator><creator>RAMI, HARSHAD KANTILAL SMITHKLINE BEECHAM PHARMA</creator><creator>JOHNSON, CHRISTOPHER N. GLAXOSMITHKLINE PHARMA</creator><creator>THEWLIS, KEVIN GLAXOSMITHKLINE PHARMACEUTICALS</creator><creator>VONG, ANTONIO, KUOK K. SMITHKLINE BEECHAM PHARMA</creator><creator>THOMPSON, MERVYN GLAXOSMITHKLINE PHARMACEUTICALS</creator><scope>EVB</scope></search><sort><creationdate>20070916</creationdate><title>DERIVADOS DE BENZOXAZINONA, SU PREPARACION Y USO</title><author>STEMP, GEOFFREY GLAXOSMITHKLINE PHARMA ; RAMI, HARSHAD KANTILAL SMITHKLINE BEECHAM PHARMA ; JOHNSON, CHRISTOPHER N. GLAXOSMITHKLINE PHARMA ; THEWLIS, KEVIN GLAXOSMITHKLINE PHARMACEUTICALS ; VONG, ANTONIO, KUOK K. SMITHKLINE BEECHAM PHARMA ; THOMPSON, MERVYN GLAXOSMITHKLINE PHARMACEUTICALS</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_ES2280417TT33</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>spa</language><creationdate>2007</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>STEMP, GEOFFREY GLAXOSMITHKLINE PHARMA</creatorcontrib><creatorcontrib>RAMI, HARSHAD KANTILAL SMITHKLINE BEECHAM PHARMA</creatorcontrib><creatorcontrib>JOHNSON, CHRISTOPHER N. GLAXOSMITHKLINE PHARMA</creatorcontrib><creatorcontrib>THEWLIS, KEVIN GLAXOSMITHKLINE PHARMACEUTICALS</creatorcontrib><creatorcontrib>VONG, ANTONIO, KUOK K. SMITHKLINE BEECHAM PHARMA</creatorcontrib><creatorcontrib>THOMPSON, MERVYN GLAXOSMITHKLINE PHARMACEUTICALS</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>STEMP, GEOFFREY GLAXOSMITHKLINE PHARMA</au><au>RAMI, HARSHAD KANTILAL SMITHKLINE BEECHAM PHARMA</au><au>JOHNSON, CHRISTOPHER N. GLAXOSMITHKLINE PHARMA</au><au>THEWLIS, KEVIN GLAXOSMITHKLINE PHARMACEUTICALS</au><au>VONG, ANTONIO, KUOK K. SMITHKLINE BEECHAM PHARMA</au><au>THOMPSON, MERVYN GLAXOSMITHKLINE PHARMACEUTICALS</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>DERIVADOS DE BENZOXAZINONA, SU PREPARACION Y USO</title><date>2007-09-16</date><risdate>2007</risdate><abstract>Un compuesto de **fórmula*o una de sus sales farmacéuticamente aceptable, en la que Ar es fenilo, naftilo, un grupo heteroaromático monocíclico o un grupo heteroaromático bicíclico, estando dicho grupo Ar opcionalmente sustituido con 1 - 4 sustituyentes, que pueden ser iguales o diferentes, y que se seleccionan del grupo que consta de: halógeno, hidroxi, ciano, nitro, trifluorometilo, trifluorometoxi, alquilo C1-6, trifluorometanosulfoniloxi, pentafluoroetilo, alcoxi C1-6, aril-alcoxi(C1-6), alquil(C1-6)-tio, alcoxi(C1-6)-alquilo- (C1-6), cicloalquil(C3-7)-alcoxi(C1-6), alcanoilo C1-6, alcoxi(C1-6)-carbonilo, alquil(C1-6)-sulfonilo, alquil(C1-6)-sulfinilo, alquil(C1-6)-sulfoniloxi, alquil(C1-6)-sulfonil-alquilo(C1-6), arilsulfonilo, arilsulfoniloxi, arilsulfonil-alquilo(C1-6), alquil(C1-6)-sulfonamido, alquil(C1-6)-amido, alquil(C1-6)-sulfonamido-alquilo(C1-6), alquil(C1-6)-amido-alquilo(C1-6), arilsulfonamido, arilcarboxamido, arilsulfonamido-alquilo(C1-6), arilcarboxamido-alquilo(C1-6), aroilo, aroil-alquilo(C1-6), aril-alcanoilo(C1-6), un grupo R3OCO(CH2)s, R3CON(R4)(CH2)s, R3R4NCO(CH2)s o R3R4NSO2(CH2)s, donde cada uno de R3 y R4 representan independientemente un átomo de hidrógeno o alquilo C1-4, o R3 y R4 forman parte de un anillo de azacicloalcano C3-6 o (2-oxo)azacicloalcano C3-6 y s representa cero o un número entero de 1 a 4.
The present invention relates to novel compounds of formula (I) or a pharmaceutically acceptable salt thereof, wherein Ar is phenyl, naphthyl, a monocyclic heteroaromatic group or a bicyclic heteroaromatic group, said Ar group being optionally substituted by 1-4 substituents, which may be the same or different, and which are selected from the group consisting of: halogen, hydroxy, cyano, nitro, trifluoromethyl, trifluoromethoxy, C1-6alkyl, trifluoromethanesulfonyloxy, pentafluoroethyl, C1-6alkoxy, arylC1-6alkoxy, C1-6alkylthio, C1-6alkoxyC1-6-alkyl, C3-7cycloalkylC1-6alkoxy, C1-6alkanoyl, C1-6alkoxycarbonyl, C1-6alkylsulfonyl, C1-6alkylsulfinyl, C1-6alkylsulfonyloxy, C1-6alkylsulfonylC1-6alkyl, arylsulfonyl, arylsulfonyloxy, arylsulfonylC1-6alkyl, C1-6alkylsulfonamido, C1-6alkylamido, C1-6alkylsulfonamidoC1-6alkyl, C1-6alkylamidoC1-6alkyl, arylsulfonamido, arylcarboxamido, alkylsulfonamidoC1-6alkyl, arylcarboxamidoC1-6alkyl, aroyl, arolC1-6alkyl, arylC1-6alkanoyl, a group R OCO(CH2)s, R CON(R )(CH2)s, R R NCO(CH2)s or R R NSO2(CH2) where each of R and R independently represents a hydrogen atom or C1-4alkyl or R and R form part of a C3-6azacyloalkane or C3-6(2-oxo)azacycloalkane ring and s represents zero or an integer from 1 to 4, and a group Ar Z, wherein Z represents a single bond, O, S or CH2 and Ar represents a phenyl or a monocyclic heteroaromatic group, said Ar group being optionally substituted by 1-3 substituents, which may be the same or different, and which are selected from the group consisting of a halogen, hydroxy, cyano, trifluoromethyl, C1-6alkyl, C1-6alkoxy or C1-6alkanoyl; when Ar is a phenyl or a monocyclic heteroaromatic group, substitutents positioned ortho to one another may be linked to form a 5- or 6-membered ring; R is hydrogen, C1-6alkyl, C3-6alkenyl, C3-6alkynyl or arylC1-6alkyl; R is halogen, C1-6alkyl, cyano, CF3, C1-6alkanoyl, C1-6alkoxy or hydroxy; X is CH or N; Y is a single bond, O, or C-O; p is 0, 1 or 2; r is 0, 1, 2 or 3; m is 2, 3 or 4; n and q are independently 1 or 2. Processes for preparing the compounds, pharmaceutical compositions containing them and their use as medicaments for various CNS disorders, including deression and/or anxiety, are also disclosed.</abstract><oa>free_for_read</oa></addata></record> |
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| language | spa |
| recordid | cdi_epo_espacenet_ES2280417TT3 |
| source | esp@cenet |
| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | DERIVADOS DE BENZOXAZINONA, SU PREPARACION Y USO |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-18T14%3A46%3A35IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=STEMP,%20GEOFFREY%20GLAXOSMITHKLINE%20PHARMA&rft.date=2007-09-16&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EES2280417TT3%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |