PROCEDIMIENTO DE PREPARACION DE EPOXIDOS QUIRALES

Un compuesto de fórmula que tiene una configuración ciclánica (1R), en la que R es un grupo alquilo C1-C4, lineal o ramificado, R¿ es hidrógeno o un grupo triorganilsililo, y R1 es un grupo alquilo, alquenilo o alquinilo C4-C6, lineal o ramificado. The invention describes novel malonates and a proce...

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Bibliographische Detailangaben
Hauptverfasser:	FEHR, CHARLES, GALINDO, JOSE, OHLEYER, ERIC
Format:	Patent
Sprache:	spa
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:	Un compuesto de fórmula que tiene una configuración ciclánica (1R), en la que R es un grupo alquilo C1-C4, lineal o ramificado, R¿ es hidrógeno o un grupo triorganilsililo, y R1 es un grupo alquilo, alquenilo o alquinilo C4-C6, lineal o ramificado. The invention describes novel malonates and a process for using said malonates for the preparation of chiral epoxides of formula having a cyclanic (1R) configuration, the group in position 2 having a transconfiguration and the epoxy group having a cis-configuration with respect to the substituent in position 1 and wherein R is an alkyl group from C1 to C4, linear or branched, and R is an alkyl or an alkenyl group from C2 to C8, linear or branched. The above process comprises the rearrangement of malonate (VII) to malonate (VI) and the decarboxylation reaction of into an ester of formula followed by the stereoselective epoxidation of the thus-obtained compound.