COMPUESTOS DE PIRIDILO Y COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN
Compuestos de piridilo de fórmula general (I), en la que - X representa H, NO2, OH, CN, F, Br, Cl, CF3, -NH-CO-CH3, 2, 3-Cl2, 2, 3-(OCH3)2, 4-Cl-3-NO2 y 2-[CH=CHCOO-C(CH3)3] y el ciclo fusionado 2, 3-oxadiazol [2.3-(=N-O-N=)]; - Y representa un grupo alcoxicarbonilo R 2 OOC-, en el que R 2 puede ser...
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| creator | STATKOW, PIERRE SUNKEL LETELIER, CARLOS FAU DE CASA-JUANA MUNOZ, MIGUEL STRAUMANN, DANIELLE ALVAREZ-BUILLA GOMEZ, JULIO CHATTERJEE, SHYAM, S |
| description | Compuestos de piridilo de fórmula general (I), en la que - X representa H, NO2, OH, CN, F, Br, Cl, CF3, -NH-CO-CH3, 2, 3-Cl2, 2, 3-(OCH3)2, 4-Cl-3-NO2 y 2-[CH=CHCOO-C(CH3)3] y el ciclo fusionado 2, 3-oxadiazol [2.3-(=N-O-N=)]; - Y representa un grupo alcoxicarbonilo R 2 OOC-, en el que R 2 puede ser H, un grupo alquilo C1-C4, 2-metoxietilo, 2-tetrahidrofurfurilo o 5, 5-dimetil-1, 3, 2-dioxafosforinan-2-il; - R representa H, un grupo alquilo C1-C4 o, alternativamente, los grupos siguientes: 2-metoxietilo, 2-(bencil-meti-lamino) etilo, 2-tetrahidrofurfurilo, 5-oxotetrahidrofururilo, 3-[(4, 4-difenil)-1-piperidinil]propilo, (R)-1-bencil-3-pipe-ridinilo, 2-(N-bencil-(N-fenilamino)-etilo, (S)-1-bencil-3-pirrolidinilo, 2-[(4-difenilmetil)-1-piperaciniletilo, 3-fenil-2- propenilo, 2-(N-morfolino)etilo o 1, 3-di(N-morfalino)isopropilo; - R¿ representa CH3, CN o -CH2-O-(CH2)2-NH2, así como los correspondiente isómeros ópticos y las sales farma-céuticamente aceptables de dichos compuestos.
The present invention is concerned with new pyridine double esters of formula (I), their acids, and pharmaceutically acceptable salts. These compounds can be obtained by oxydation of the corresponding 1,4-dihydropyridines, and they are useful as cardioprotective agents in pharmaceutical compositions. |
| format | Patent |
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The present invention is concerned with new pyridine double esters of formula (I), their acids, and pharmaceutically acceptable salts. These compounds can be obtained by oxydation of the corresponding 1,4-dihydropyridines, and they are useful as cardioprotective agents in pharmaceutical compositions.</description><edition>7</edition><language>spa</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2004</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20040516&DB=EPODOC&CC=ES&NR=2206989T3$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20040516&DB=EPODOC&CC=ES&NR=2206989T3$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>STATKOW, PIERRE</creatorcontrib><creatorcontrib>SUNKEL LETELIER, CARLOS</creatorcontrib><creatorcontrib>FAU DE CASA-JUANA MUNOZ, MIGUEL</creatorcontrib><creatorcontrib>STRAUMANN, DANIELLE</creatorcontrib><creatorcontrib>ALVAREZ-BUILLA GOMEZ, JULIO</creatorcontrib><creatorcontrib>CHATTERJEE, SHYAM, S</creatorcontrib><title>COMPUESTOS DE PIRIDILO Y COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN</title><description>Compuestos de piridilo de fórmula general (I), en la que - X representa H, NO2, OH, CN, F, Br, Cl, CF3, -NH-CO-CH3, 2, 3-Cl2, 2, 3-(OCH3)2, 4-Cl-3-NO2 y 2-[CH=CHCOO-C(CH3)3] y el ciclo fusionado 2, 3-oxadiazol [2.3-(=N-O-N=)]; - Y representa un grupo alcoxicarbonilo R 2 OOC-, en el que R 2 puede ser H, un grupo alquilo C1-C4, 2-metoxietilo, 2-tetrahidrofurfurilo o 5, 5-dimetil-1, 3, 2-dioxafosforinan-2-il; - R representa H, un grupo alquilo C1-C4 o, alternativamente, los grupos siguientes: 2-metoxietilo, 2-(bencil-meti-lamino) etilo, 2-tetrahidrofurfurilo, 5-oxotetrahidrofururilo, 3-[(4, 4-difenil)-1-piperidinil]propilo, (R)-1-bencil-3-pipe-ridinilo, 2-(N-bencil-(N-fenilamino)-etilo, (S)-1-bencil-3-pirrolidinilo, 2-[(4-difenilmetil)-1-piperaciniletilo, 3-fenil-2- propenilo, 2-(N-morfolino)etilo o 1, 3-di(N-morfalino)isopropilo; - R¿ representa CH3, CN o -CH2-O-(CH2)2-NH2, así como los correspondiente isómeros ópticos y las sales farma-céuticamente aceptables de dichos compuestos.
The present invention is concerned with new pyridine double esters of formula (I), their acids, and pharmaceutically acceptable salts. These compounds can be obtained by oxydation of the corresponding 1,4-dihydropyridines, and they are useful as cardioprotective agents in pharmaceutical compositions.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2004</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZHBz9vcNCHUNDvEPVnBxVQjwDPJ08fTxV4hUAEn4B3s6e_r7uQYruDkG-To6u4aGeDo7BisEhroq-AB1OPv7hXi6-rn68TCwpiXmFKfyQmluBkU31xBnD93Ugvz41OKCxOTUvNSSeNdgIyMDM0sLy5AQY2Ni1AAA3HYtFg</recordid><startdate>20040516</startdate><enddate>20040516</enddate><creator>STATKOW, PIERRE</creator><creator>SUNKEL LETELIER, CARLOS</creator><creator>FAU DE CASA-JUANA MUNOZ, MIGUEL</creator><creator>STRAUMANN, DANIELLE</creator><creator>ALVAREZ-BUILLA GOMEZ, JULIO</creator><creator>CHATTERJEE, SHYAM, S</creator><scope>EVB</scope></search><sort><creationdate>20040516</creationdate><title>COMPUESTOS DE PIRIDILO Y COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN</title><author>STATKOW, PIERRE ; SUNKEL LETELIER, CARLOS ; FAU DE CASA-JUANA MUNOZ, MIGUEL ; STRAUMANN, DANIELLE ; ALVAREZ-BUILLA GOMEZ, JULIO ; CHATTERJEE, SHYAM, S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_ES2206989TT33</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>spa</language><creationdate>2004</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>STATKOW, PIERRE</creatorcontrib><creatorcontrib>SUNKEL LETELIER, CARLOS</creatorcontrib><creatorcontrib>FAU DE CASA-JUANA MUNOZ, MIGUEL</creatorcontrib><creatorcontrib>STRAUMANN, DANIELLE</creatorcontrib><creatorcontrib>ALVAREZ-BUILLA GOMEZ, JULIO</creatorcontrib><creatorcontrib>CHATTERJEE, SHYAM, S</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>STATKOW, PIERRE</au><au>SUNKEL LETELIER, CARLOS</au><au>FAU DE CASA-JUANA MUNOZ, MIGUEL</au><au>STRAUMANN, DANIELLE</au><au>ALVAREZ-BUILLA GOMEZ, JULIO</au><au>CHATTERJEE, SHYAM, S</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>COMPUESTOS DE PIRIDILO Y COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN</title><date>2004-05-16</date><risdate>2004</risdate><abstract>Compuestos de piridilo de fórmula general (I), en la que - X representa H, NO2, OH, CN, F, Br, Cl, CF3, -NH-CO-CH3, 2, 3-Cl2, 2, 3-(OCH3)2, 4-Cl-3-NO2 y 2-[CH=CHCOO-C(CH3)3] y el ciclo fusionado 2, 3-oxadiazol [2.3-(=N-O-N=)]; - Y representa un grupo alcoxicarbonilo R 2 OOC-, en el que R 2 puede ser H, un grupo alquilo C1-C4, 2-metoxietilo, 2-tetrahidrofurfurilo o 5, 5-dimetil-1, 3, 2-dioxafosforinan-2-il; - R representa H, un grupo alquilo C1-C4 o, alternativamente, los grupos siguientes: 2-metoxietilo, 2-(bencil-meti-lamino) etilo, 2-tetrahidrofurfurilo, 5-oxotetrahidrofururilo, 3-[(4, 4-difenil)-1-piperidinil]propilo, (R)-1-bencil-3-pipe-ridinilo, 2-(N-bencil-(N-fenilamino)-etilo, (S)-1-bencil-3-pirrolidinilo, 2-[(4-difenilmetil)-1-piperaciniletilo, 3-fenil-2- propenilo, 2-(N-morfolino)etilo o 1, 3-di(N-morfalino)isopropilo; - R¿ representa CH3, CN o -CH2-O-(CH2)2-NH2, así como los correspondiente isómeros ópticos y las sales farma-céuticamente aceptables de dichos compuestos.
The present invention is concerned with new pyridine double esters of formula (I), their acids, and pharmaceutically acceptable salts. These compounds can be obtained by oxydation of the corresponding 1,4-dihydropyridines, and they are useful as cardioprotective agents in pharmaceutical compositions.</abstract><edition>7</edition><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | COMPUESTOS DE PIRIDILO Y COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN |
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