ESTERES DE 1,4-DIHIDROPIRIDINA 4-FENIL-3-SUSTITUIDOS

LOS ESTERES 1,4 - DIHIDRO PIRIDINA 4 - FENIL - 3 - SUSTITUIDOS SE ELABORAN MEDIANTE TRANSFORMACION DE BENZALDEHIDOS CON CETOESTER Y ENAMINAS EVENTUALMENTE BAJO AISLAMIENTO DE PRODUCTO INTERMEDIO ILIDENO, O MEDIANTE ESTERIFICACION DE LOS ACIDOS CARBOXILICOS DIHIDROPIRIDINA CORRESPONDIENTES CON ALCOHO...

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Hauptverfasser: GAO, ZHAN DR, SCHOHE-LOOP, RUDOLF DR, MEIER, HEINRICH DR, HARTWIG, WOLFGANG DR, JUNGE, BODO DR, SCHMIDT, BERNARD DR
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creator GAO, ZHAN DR
SCHOHE-LOOP, RUDOLF DR
MEIER, HEINRICH DR
HARTWIG, WOLFGANG DR
JUNGE, BODO DR
SCHMIDT, BERNARD DR
description LOS ESTERES 1,4 - DIHIDRO PIRIDINA 4 - FENIL - 3 - SUSTITUIDOS SE ELABORAN MEDIANTE TRANSFORMACION DE BENZALDEHIDOS CON CETOESTER Y ENAMINAS EVENTUALMENTE BAJO AISLAMIENTO DE PRODUCTO INTERMEDIO ILIDENO, O MEDIANTE ESTERIFICACION DE LOS ACIDOS CARBOXILICOS DIHIDROPIRIDINA CORRESPONDIENTES CON ALCOHOLES. LOS NUEVOS ESTERES 1,4 - DIHIDROPIRIDINA 4 - FENIL - 3 SUSTITUIDOS PUEDEN SER UTILIZADOS COMO SUSTANCIA ACTIVA EN MEDICAMENTO PARA TRATAMIENTO DEL SISTEMA NERVIOSO CENTRAL, EN PARTICULAR COMO PRODUCTO TERAPEUTICO CEREBRAL. 4-Phenyl 3-substituted 1,4-dihydropyridine esters are prepared by reacting benzaldehydes with keto esters and enamines, where appropriate with isolation of ylidene intermediates, or by esterification of corresponding dihydropyridinecarboxylic acids with alcohols. The 4-phenyl 3-substituted 1,4-dihydropyridine esters can be used as active ingredients in pharmaceuticals for the treatment of the central nervous system, in particular as cerebral therapeutic agents.
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title ESTERES DE 1,4-DIHIDROPIRIDINA 4-FENIL-3-SUSTITUIDOS
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