COMPUESTOS PENTACICLICOS, INTERMEDIARIOS, PROCESOS, COMPOSICIONES Y PROCEDIMIENTOS

LA PRESENTE INVENCION SE REFIERE A COMPUESTOS DE FORMULAS I Y II; DONDE X ES -O-, -S-, O -NR{SUP,5}-; Y ES -O-, -S-, -CH{SUB,2}-, -CH{SUB,2}CH{SUB,2}-, -CH=CH-, O -NR{SUP,5}-; B ES -CH{SUB,2}- O -CO-; R{SUP,1}, R{SUP,2} Y R{SUP,3} SON CADA UNO INDEPENDIENTEMENTE -H, -OH, -O(ALQUILO C{SUB,1}-C{SUB,4}...

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1. Verfasser:	GRESE, TIMOTHY ALAN
Format:	Patent
Sprache:	spa
Schlagworte:	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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creator	GRESE, TIMOTHY ALAN
description	LA PRESENTE INVENCION SE REFIERE A COMPUESTOS DE FORMULAS I Y II; DONDE X ES -O-, -S-, O -NR{SUP,5}-; Y ES -O-, -S-, -CH{SUB,2}-, -CH{SUB,2}CH{SUB,2}-, -CH=CH-, O -NR{SUP,5}-; B ES -CH{SUB,2}- O -CO-; R{SUP,1}, R{SUP,2} Y R{SUP,3} SON CADA UNO INDEPENDIENTEMENTE -H, -OH, -O(ALQUILO C{SUB,1}-C{SUB,4}), -OCO(ALQUILO C{SUB,1}C{SUB,6}), -OSO{SUB,2}(ALQUILO C{SUB,4}-C{SUB,6}, OSO{SUB,2}CF{SUB,3}, CL O F; N ES 1 O 2; W ES CH{SUB,2} O C=O; R{SUP,4} ES 1-PIPERIDINIL, 2-OXO-1-PIPERIDINIL, 1-PIRROLIDINIL, METIL-1-PIRROLIDINIL, DIMETIL-1-PIRROLIDINIL, 2-OXO-1PIRROLIDINIL, 4-MORFOLINO, DIMETILAMINO, DIETILAMINO, O 1HEXAMETILENOIMINO; R{SUP,5} ES ALQUILO C{SUB,1}-C{SUB,3}, -COC{SUB,6}H{SUB,5}, CO(ALQUILO C{SUB,1}-C{SUB,6}), -C(O)OC{SUB,6}H{SUB,5}, -C(O)O(ALQUILO C{SUB,1}-C{SUB,6}), -SO{SUB,2}C{SUB,6}H{SUB,5}, O -SO{SUB,2}CF{SUB,3}, O UNA SAL FARMACEUTICAMENTE ACEPTABLE DEL MISMO. TAMBIEN SE PROPORCIONAN EN LA PRESENTE INVENCION COMPUESTOS INTERMEDIOS; PROCEDIMIENTOS DE PREPARACION DE LOS COMPUESTOS DE FORMULAS I Y II; Y METODOS FARMACEUTICOS Y FORMULACIONES QUE EMPLEAN DICHOS COMPUESTOS. The present invention relates to compounds of formula I and II; wherein X is -O-, -S-, or -NR -; Y is -O-, -S-, -CH2-, -CH2CH2-, -CH=CH-, or -NR -; B is -CH - or -CO-; R , R , and R are each independently -H, -OH, -O(C1-C4 alkyl), -OCOC6H5, -OCO(C1-C6 alkyl), -OSO2(C4-C6 alkyl), -OSO2CF3, Cl, or F; n is 1 or 2; W is CH2 or C=O; R is 1-piperidinyl, 2-oxo-1-piperidinyl, 1-pyrrolidinyl, methyl-1-pyrrolidinyl, dimethyl-1-pyrrolidinyl, 2-oxo-1-pyrrolidinyl, 4-morpholino, dimethylamino, diethylamino, or 1-hexamethyleneimino; R is C1-C3 alkyl, -COC6H5, -CO(C1-C6 alkyl), -C(O)OC6H5, -C(O)O(C1-C6 alkyl), -SO2(C1-C6 alkyl), -SO2C6H5, or -SO2CF3; or a pharmaceutically acceptable salt thereof. Also provided by the present invention are intermediate compounds; processes for the preparation of compounds of Formulae I and II; and pharmaceutical methods and formulations employing the compounds of Formulae I and II.
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TAMBIEN SE PROPORCIONAN EN LA PRESENTE INVENCION COMPUESTOS INTERMEDIOS; PROCEDIMIENTOS DE PREPARACION DE LOS COMPUESTOS DE FORMULAS I Y II; Y METODOS FARMACEUTICOS Y FORMULACIONES QUE EMPLEAN DICHOS COMPUESTOS. The present invention relates to compounds of formula I and II; wherein X is -O-, -S-, or -NR -; Y is -O-, -S-, -CH2-, -CH2CH2-, -CH=CH-, or -NR -; B is -CH - or -CO-; R , R , and R are each independently -H, -OH, -O(C1-C4 alkyl), -OCOC6H5, -OCO(C1-C6 alkyl), -OSO2(C4-C6 alkyl), -OSO2CF3, Cl, or F; n is 1 or 2; W is CH2 or C=O; R is 1-piperidinyl, 2-oxo-1-piperidinyl, 1-pyrrolidinyl, methyl-1-pyrrolidinyl, dimethyl-1-pyrrolidinyl, 2-oxo-1-pyrrolidinyl, 4-morpholino, dimethylamino, diethylamino, or 1-hexamethyleneimino; R is C1-C3 alkyl, -COC6H5, -CO(C1-C6 alkyl), -C(O)OC6H5, -C(O)O(C1-C6 alkyl), -SO2(C1-C6 alkyl), -SO2C6H5, or -SO2CF3; or a pharmaceutically acceptable salt thereof. Also provided by the present invention are intermediate compounds; processes for the preparation of compounds of Formulae I and II; and pharmaceutical methods and formulations employing the compounds of Formulae I and II.</description><edition>7</edition><language>spa</language><subject>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM ; CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2001</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20010201&DB=EPODOC&CC=ES&NR=2152496T3$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20010201&DB=EPODOC&CC=ES&NR=2152496T3$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>GRESE, TIMOTHY ALAN</creatorcontrib><title>COMPUESTOS PENTACICLICOS, INTERMEDIARIOS, PROCESOS, COMPOSICIONES Y PROCEDIMIENTOS</title><description>LA PRESENTE INVENCION SE REFIERE A COMPUESTOS DE FORMULAS I Y II; DONDE X ES -O-, -S-, O -NR{SUP,5}-; Y ES -O-, -S-, -CH{SUB,2}-, -CH{SUB,2}CH{SUB,2}-, -CH=CH-, O -NR{SUP,5}-; B ES -CH{SUB,2}- O -CO-; R{SUP,1}, R{SUP,2} Y R{SUP,3} SON CADA UNO INDEPENDIENTEMENTE -H, -OH, -O(ALQUILO C{SUB,1}-C{SUB,4}), -OCO(ALQUILO C{SUB,1}C{SUB,6}), -OSO{SUB,2}(ALQUILO C{SUB,4}-C{SUB,6}, OSO{SUB,2}CF{SUB,3}, CL O F; N ES 1 O 2; W ES CH{SUB,2} O C=O; R{SUP,4} ES 1-PIPERIDINIL, 2-OXO-1-PIPERIDINIL, 1-PIRROLIDINIL, METIL-1-PIRROLIDINIL, DIMETIL-1-PIRROLIDINIL, 2-OXO-1PIRROLIDINIL, 4-MORFOLINO, DIMETILAMINO, DIETILAMINO, O 1HEXAMETILENOIMINO; R{SUP,5} ES ALQUILO C{SUB,1}-C{SUB,3}, -COC{SUB,6}H{SUB,5}, CO(ALQUILO C{SUB,1}-C{SUB,6}), -C(O)OC{SUB,6}H{SUB,5}, -C(O)O(ALQUILO C{SUB,1}-C{SUB,6}), -SO{SUB,2}C{SUB,6}H{SUB,5}, O -SO{SUB,2}CF{SUB,3}, O UNA SAL FARMACEUTICAMENTE ACEPTABLE DEL MISMO. TAMBIEN SE PROPORCIONAN EN LA PRESENTE INVENCION COMPUESTOS INTERMEDIOS; PROCEDIMIENTOS DE PREPARACION DE LOS COMPUESTOS DE FORMULAS I Y II; Y METODOS FARMACEUTICOS Y FORMULACIONES QUE EMPLEAN DICHOS COMPUESTOS. The present invention relates to compounds of formula I and II; wherein X is -O-, -S-, or -NR -; Y is -O-, -S-, -CH2-, -CH2CH2-, -CH=CH-, or -NR -; B is -CH - or -CO-; R , R , and R are each independently -H, -OH, -O(C1-C4 alkyl), -OCOC6H5, -OCO(C1-C6 alkyl), -OSO2(C4-C6 alkyl), -OSO2CF3, Cl, or F; n is 1 or 2; W is CH2 or C=O; R is 1-piperidinyl, 2-oxo-1-piperidinyl, 1-pyrrolidinyl, methyl-1-pyrrolidinyl, dimethyl-1-pyrrolidinyl, 2-oxo-1-pyrrolidinyl, 4-morpholino, dimethylamino, diethylamino, or 1-hexamethyleneimino; R is C1-C3 alkyl, -COC6H5, -CO(C1-C6 alkyl), -C(O)OC6H5, -C(O)O(C1-C6 alkyl), -SO2(C1-C6 alkyl), -SO2C6H5, or -SO2CF3; or a pharmaceutically acceptable salt thereof. Also provided by the present invention are intermediate compounds; processes for the preparation of compounds of Formulae I and II; and pharmaceutical methods and formulations employing the compounds of Formulae I and II.</description><subject>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM</subject><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2001</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZAhy9vcNCHUNDvEPVghw9QtxdPZ09vF09g_WUfD0C3EN8nV18XQM8gTxA4L8nV2DQSyQHv9gT2dPfz_XYIVIiIyLp68n0AD_YB4G1rTEnOJUXijNzaDo5hri7KGbWpAfn1pckJicmpdaEu8abGRoamRiaRYSYmxMjBoALigwsg</recordid><startdate>20010201</startdate><enddate>20010201</enddate><creator>GRESE, TIMOTHY ALAN</creator><scope>EVB</scope></search><sort><creationdate>20010201</creationdate><title>COMPUESTOS PENTACICLICOS, INTERMEDIARIOS, PROCESOS, COMPOSICIONES Y PROCEDIMIENTOS</title><author>GRESE, TIMOTHY ALAN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_ES2152496TT33</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>spa</language><creationdate>2001</creationdate><topic>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM</topic><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>GRESE, TIMOTHY ALAN</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>GRESE, TIMOTHY ALAN</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>COMPUESTOS PENTACICLICOS, INTERMEDIARIOS, PROCESOS, COMPOSICIONES Y PROCEDIMIENTOS</title><date>2001-02-01</date><risdate>2001</risdate><abstract>LA PRESENTE INVENCION SE REFIERE A COMPUESTOS DE FORMULAS I Y II; DONDE X ES -O-, -S-, O -NR{SUP,5}-; Y ES -O-, -S-, -CH{SUB,2}-, -CH{SUB,2}CH{SUB,2}-, -CH=CH-, O -NR{SUP,5}-; B ES -CH{SUB,2}- O -CO-; R{SUP,1}, R{SUP,2} Y R{SUP,3} SON CADA UNO INDEPENDIENTEMENTE -H, -OH, -O(ALQUILO C{SUB,1}-C{SUB,4}), -OCO(ALQUILO C{SUB,1}C{SUB,6}), -OSO{SUB,2}(ALQUILO C{SUB,4}-C{SUB,6}, OSO{SUB,2}CF{SUB,3}, CL O F; N ES 1 O 2; W ES CH{SUB,2} O C=O; R{SUP,4} ES 1-PIPERIDINIL, 2-OXO-1-PIPERIDINIL, 1-PIRROLIDINIL, METIL-1-PIRROLIDINIL, DIMETIL-1-PIRROLIDINIL, 2-OXO-1PIRROLIDINIL, 4-MORFOLINO, DIMETILAMINO, DIETILAMINO, O 1HEXAMETILENOIMINO; R{SUP,5} ES ALQUILO C{SUB,1}-C{SUB,3}, -COC{SUB,6}H{SUB,5}, CO(ALQUILO C{SUB,1}-C{SUB,6}), -C(O)OC{SUB,6}H{SUB,5}, -C(O)O(ALQUILO C{SUB,1}-C{SUB,6}), -SO{SUB,2}C{SUB,6}H{SUB,5}, O -SO{SUB,2}CF{SUB,3}, O UNA SAL FARMACEUTICAMENTE ACEPTABLE DEL MISMO. TAMBIEN SE PROPORCIONAN EN LA PRESENTE INVENCION COMPUESTOS INTERMEDIOS; PROCEDIMIENTOS DE PREPARACION DE LOS COMPUESTOS DE FORMULAS I Y II; Y METODOS FARMACEUTICOS Y FORMULACIONES QUE EMPLEAN DICHOS COMPUESTOS. The present invention relates to compounds of formula I and II; wherein X is -O-, -S-, or -NR -; Y is -O-, -S-, -CH2-, -CH2CH2-, -CH=CH-, or -NR -; B is -CH - or -CO-; R , R , and R are each independently -H, -OH, -O(C1-C4 alkyl), -OCOC6H5, -OCO(C1-C6 alkyl), -OSO2(C4-C6 alkyl), -OSO2CF3, Cl, or F; n is 1 or 2; W is CH2 or C=O; R is 1-piperidinyl, 2-oxo-1-piperidinyl, 1-pyrrolidinyl, methyl-1-pyrrolidinyl, dimethyl-1-pyrrolidinyl, 2-oxo-1-pyrrolidinyl, 4-morpholino, dimethylamino, diethylamino, or 1-hexamethyleneimino; R is C1-C3 alkyl, -COC6H5, -CO(C1-C6 alkyl), -C(O)OC6H5, -C(O)O(C1-C6 alkyl), -SO2(C1-C6 alkyl), -SO2C6H5, or -SO2CF3; or a pharmaceutically acceptable salt thereof. Also provided by the present invention are intermediate compounds; processes for the preparation of compounds of Formulae I and II; and pharmaceutical methods and formulations employing the compounds of Formulae I and II.</abstract><edition>7</edition><oa>free_for_read</oa></addata></record>
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subjects	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title	COMPUESTOS PENTACICLICOS, INTERMEDIARIOS, PROCESOS, COMPOSICIONES Y PROCEDIMIENTOS
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