ALFA B CRISTALINA PARA USO EN EL DIAGNOSTICO Y EL TRATAMIENTO DE ENFERMEDADES AUTO-INMUNES Y EN PARTICULAR LA ESCLEROSIS MULTIPLE
LA INVENCION SE REFIERE AL PRIMER USO MEDICO DE LA CRISTALINA ALFA B O DE LOS DERIVADOS DE LA MISMA EN EL CAMPO DE LAS ENFERMEDADES AUTOINMUNES, PARTICULARMENTE LA ESCLEROSIS MULTIPLE. TAMBIEN SE PRESENTAN METODOS Y HERRAMIENTAS DE DIAGNOSTICO BASADOS EN LA CRISTALINA ALFA B PARA LA DETECCION DE LA...
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| creator | VAN SECHEL, ARIANNE, C OUAGMIRI, MUSTAPHA, EL VAN NOORT, JOHANNES, M |
| description | LA INVENCION SE REFIERE AL PRIMER USO MEDICO DE LA CRISTALINA ALFA B O DE LOS DERIVADOS DE LA MISMA EN EL CAMPO DE LAS ENFERMEDADES AUTOINMUNES, PARTICULARMENTE LA ESCLEROSIS MULTIPLE. TAMBIEN SE PRESENTAN METODOS Y HERRAMIENTAS DE DIAGNOSTICO BASADOS EN LA CRISTALINA ALFA B PARA LA DETECCION DE LA ESCLEROSIS MULTIPLE. LA CRISTALINA ALFA B HUMANA ES UNA PROTEINA CONOCIDA POR SI MISMA, QUE SE SABE QUE ESTA PRESENTE EN EL OJO Y EN PEQUEÑAS CANTIDADES EN LA MATERIA BLANCA DEL SISTEMA NERVIOSO, QUE ES AFECTADA POR LA ESCLEROSIS MULTIPLE. UTILIZANDO UNA NUEVA APROXIMACION PARA COMPROBAR LA CAPACIDAD DE INDUCIR AUTOINMUNIDAD, LA CRISTALINA ALFA B HA MOSTRADO MEDIANTE LA PRESENTE INVENCION SER UN AUTOANTIGENO IMPORTANTE. LOS METODOS TAMBIEN FORMAN PARTE DE LA INVENCION.
The present invention discloses the first medical use of alpha B crystallin or derivatives thereof in the field of auto-immune diseases, particularly multiple sclerosis. It also discloses diagnostic methods and tools therefor based upon alpha B crystallin for the detection of multiple sclerosis. Human alpha B crystallin is a known protein in itself, known to be present in the eye and in small amounts in the white matter of the nerve system, which is affected by multiple sclerosis. By using a novel and inventive approach to test for ability to induce auto-immunity, alpha B crystallin has been shown by the present invention to be an important auto-antigen. Such methods are also part of the invention. |
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The present invention discloses the first medical use of alpha B crystallin or derivatives thereof in the field of auto-immune diseases, particularly multiple sclerosis. It also discloses diagnostic methods and tools therefor based upon alpha B crystallin for the detection of multiple sclerosis. Human alpha B crystallin is a known protein in itself, known to be present in the eye and in small amounts in the white matter of the nerve system, which is affected by multiple sclerosis. By using a novel and inventive approach to test for ability to induce auto-immunity, alpha B crystallin has been shown by the present invention to be an important auto-antigen. Such methods are also part of the invention.</description><edition>6</edition><language>spa</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; HUMAN NECESSITIES ; HYGIENE ; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES ; MEASURING ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; ORGANIC CHEMISTRY ; PEPTIDES ; PHYSICS ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SPIRITS ; TESTING ; VINEGAR ; WINE</subject><creationdate>1999</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19990301&DB=EPODOC&CC=ES&NR=2125618T3$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25543,76293</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19990301&DB=EPODOC&CC=ES&NR=2125618T3$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>VAN SECHEL, ARIANNE, C</creatorcontrib><creatorcontrib>OUAGMIRI, MUSTAPHA, EL</creatorcontrib><creatorcontrib>VAN NOORT, JOHANNES, M</creatorcontrib><title>ALFA B CRISTALINA PARA USO EN EL DIAGNOSTICO Y EL TRATAMIENTO DE ENFERMEDADES AUTO-INMUNES Y EN PARTICULAR LA ESCLEROSIS MULTIPLE</title><description>LA INVENCION SE REFIERE AL PRIMER USO MEDICO DE LA CRISTALINA ALFA B O DE LOS DERIVADOS DE LA MISMA EN EL CAMPO DE LAS ENFERMEDADES AUTOINMUNES, PARTICULARMENTE LA ESCLEROSIS MULTIPLE. TAMBIEN SE PRESENTAN METODOS Y HERRAMIENTAS DE DIAGNOSTICO BASADOS EN LA CRISTALINA ALFA B PARA LA DETECCION DE LA ESCLEROSIS MULTIPLE. LA CRISTALINA ALFA B HUMANA ES UNA PROTEINA CONOCIDA POR SI MISMA, QUE SE SABE QUE ESTA PRESENTE EN EL OJO Y EN PEQUEÑAS CANTIDADES EN LA MATERIA BLANCA DEL SISTEMA NERVIOSO, QUE ES AFECTADA POR LA ESCLEROSIS MULTIPLE. UTILIZANDO UNA NUEVA APROXIMACION PARA COMPROBAR LA CAPACIDAD DE INDUCIR AUTOINMUNIDAD, LA CRISTALINA ALFA B HA MOSTRADO MEDIANTE LA PRESENTE INVENCION SER UN AUTOANTIGENO IMPORTANTE. LOS METODOS TAMBIEN FORMAN PARTE DE LA INVENCION.
The present invention discloses the first medical use of alpha B crystallin or derivatives thereof in the field of auto-immune diseases, particularly multiple sclerosis. It also discloses diagnostic methods and tools therefor based upon alpha B crystallin for the detection of multiple sclerosis. Human alpha B crystallin is a known protein in itself, known to be present in the eye and in small amounts in the white matter of the nerve system, which is affected by multiple sclerosis. By using a novel and inventive approach to test for ability to induce auto-immunity, alpha B crystallin has been shown by the present invention to be an important auto-antigen. Such methods are also part of the invention.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</subject><subject>MEASURING</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PHYSICS</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>SPIRITS</subject><subject>TESTING</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1999</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNjE0KwjAQhbtxIeodxgN00RbF7ZhMNZCfkkwWXZUicSVaqBfw5qbgAVw93uN737r4oG4RziC8CoxaWYQOPUIMDsgCaZAKL9YFVsJBvwzskdEosuxAUqZa8oYkSgqAkV2prIk2l34xZFu-Ro0eNAIFocm7oAKYqFl1mrbF6j4-5rT75abYt8TiWqbpNaR5Gm_pmd4DhbqqD8fqxNw0_zBfR2w8ag</recordid><startdate>19990301</startdate><enddate>19990301</enddate><creator>VAN SECHEL, ARIANNE, C</creator><creator>OUAGMIRI, MUSTAPHA, EL</creator><creator>VAN NOORT, JOHANNES, M</creator><scope>EVB</scope></search><sort><creationdate>19990301</creationdate><title>ALFA B CRISTALINA PARA USO EN EL DIAGNOSTICO Y EL TRATAMIENTO DE ENFERMEDADES AUTO-INMUNES Y EN PARTICULAR LA ESCLEROSIS MULTIPLE</title><author>VAN SECHEL, ARIANNE, C ; OUAGMIRI, MUSTAPHA, EL ; VAN NOORT, JOHANNES, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_ES2125618TT33</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>spa</language><creationdate>1999</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</topic><topic>MEASURING</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PHYSICS</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>SPIRITS</topic><topic>TESTING</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>VAN SECHEL, ARIANNE, C</creatorcontrib><creatorcontrib>OUAGMIRI, MUSTAPHA, EL</creatorcontrib><creatorcontrib>VAN NOORT, JOHANNES, M</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>VAN SECHEL, ARIANNE, C</au><au>OUAGMIRI, MUSTAPHA, EL</au><au>VAN NOORT, JOHANNES, M</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>ALFA B CRISTALINA PARA USO EN EL DIAGNOSTICO Y EL TRATAMIENTO DE ENFERMEDADES AUTO-INMUNES Y EN PARTICULAR LA ESCLEROSIS MULTIPLE</title><date>1999-03-01</date><risdate>1999</risdate><abstract>LA INVENCION SE REFIERE AL PRIMER USO MEDICO DE LA CRISTALINA ALFA B O DE LOS DERIVADOS DE LA MISMA EN EL CAMPO DE LAS ENFERMEDADES AUTOINMUNES, PARTICULARMENTE LA ESCLEROSIS MULTIPLE. TAMBIEN SE PRESENTAN METODOS Y HERRAMIENTAS DE DIAGNOSTICO BASADOS EN LA CRISTALINA ALFA B PARA LA DETECCION DE LA ESCLEROSIS MULTIPLE. LA CRISTALINA ALFA B HUMANA ES UNA PROTEINA CONOCIDA POR SI MISMA, QUE SE SABE QUE ESTA PRESENTE EN EL OJO Y EN PEQUEÑAS CANTIDADES EN LA MATERIA BLANCA DEL SISTEMA NERVIOSO, QUE ES AFECTADA POR LA ESCLEROSIS MULTIPLE. UTILIZANDO UNA NUEVA APROXIMACION PARA COMPROBAR LA CAPACIDAD DE INDUCIR AUTOINMUNIDAD, LA CRISTALINA ALFA B HA MOSTRADO MEDIANTE LA PRESENTE INVENCION SER UN AUTOANTIGENO IMPORTANTE. LOS METODOS TAMBIEN FORMAN PARTE DE LA INVENCION.
The present invention discloses the first medical use of alpha B crystallin or derivatives thereof in the field of auto-immune diseases, particularly multiple sclerosis. It also discloses diagnostic methods and tools therefor based upon alpha B crystallin for the detection of multiple sclerosis. Human alpha B crystallin is a known protein in itself, known to be present in the eye and in small amounts in the white matter of the nerve system, which is affected by multiple sclerosis. By using a novel and inventive approach to test for ability to induce auto-immunity, alpha B crystallin has been shown by the present invention to be an important auto-antigen. Such methods are also part of the invention.</abstract><edition>6</edition><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING VINEGAR WINE |
| title | ALFA B CRISTALINA PARA USO EN EL DIAGNOSTICO Y EL TRATAMIENTO DE ENFERMEDADES AUTO-INMUNES Y EN PARTICULAR LA ESCLEROSIS MULTIPLE |
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