NEW PROCESS FOR PREPARING (-)-TRANS-N-p-FLUOROBENZOYLMETHYL-4-(p-FLUOROPHENYL)-3- 3,4-(METHYLENEDIOXY)PHENOXY]METHYL]-PIPERIDINE

NEW PROCESS FOR PREPARING (-)-TRANS-N-p-FLUOROBENZOYLMETHYL-4-(p-FLUOROPHENYL)-3- 3,4-(METHYLENEDIOXY)PHENOXY]METHYL]-PIPERIDINE

The process consists in reacting (-)-trans-N-(p-fluorophenyl)-3-[[3,4-(methylenedioxy)phenoxy]methyl]-piperidine acetate with 2-chloro- or 2-bromo-4'-fluoroacetophenone, and the resulting compound can be isolated as a pharmaceutically acceptable addition salt by reaction with the corresponding...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: FOGUET AMBROS RAFAEL, GUBERT RIBERA SANTIAGO
Format: Patent
Sprache:eng ; spa
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The process consists in reacting (-)-trans-N-(p-fluorophenyl)-3-[[3,4-(methylenedioxy)phenoxy]methyl]-piperidine acetate with 2-chloro- or 2-bromo-4'-fluoroacetophenone, and the resulting compound can be isolated as a pharmaceutically acceptable addition salt by reaction with the corresponding acid. NUEVO PROCEDIMIENTO DE OBTENCION DE (-)-TRANS-N-P-FLUOROBENZOILMETIL-4-(P-FLUOROFENIL)-3-[[3,4-(METILENDIOXI)FENOXI]METIL]-PIPERIDINA. CONSISTE EN HACER REACCIONAR ACETATO DE (-)-TRANS-4-(P-FLUOROFENIL)-3-[[3,4-(METILENDIOXI)FENOXI]METIL]-PIPERIDINA CON 2-CLORO (O BROMO)-4''-FLUORO-ACETOFENONA, PUDIENDOSE AISLAR EL COMPUESTO RESULTANTE COMO SAL DE ADICION FARMACEUTICAMENTE ACEPTABLE POR REACCION CON EL ACIDO CORRESPONDIENTE.