1,4-DIHIDROPIRIDINA-ENANTIOMEROS
LAS ENANTIOMEROS DE DIHIDROPIRIDINAS PUROS DE FORMULA (I) EN LA QUE LOS SUSTITUYENTES Y SIMBOLOS TIENEN EL SIGNIFICADO QUE SE INDICA EN LA DESCRIPCION SON COMPUESTOS NUEVOS CON PROPIEDADES FARMACOLOGICAS SORPRENDENTES. SE DESCRIBE UN NUEVO PROCEDIMIENTO PARA LA OBTENCION DE ESTOS COMPUESTOS. PCT No....
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| creator | SCHUDT, CHRISTIAN SANDERS, KARL AMSCHLER, HERMANN ELTZE, MANFRID KLEMM, KURT, DR KOLASSA, NORBERT, DR FLOCKERZI, DIETER EISTETTER, KLAUS KOHL, BERNHARD ULRICH, WOLF-RUDIGER |
| description | LAS ENANTIOMEROS DE DIHIDROPIRIDINAS PUROS DE FORMULA (I) EN LA QUE LOS SUSTITUYENTES Y SIMBOLOS TIENEN EL SIGNIFICADO QUE SE INDICA EN LA DESCRIPCION SON COMPUESTOS NUEVOS CON PROPIEDADES FARMACOLOGICAS SORPRENDENTES. SE DESCRIBE UN NUEVO PROCEDIMIENTO PARA LA OBTENCION DE ESTOS COMPUESTOS.
PCT No. PCT/EP88/00239 Sec. 371 Date Sep. 19, 1989 Sec. 102(e) Date Sep. 19, 1989 PCT Filed Mar. 24, 1988 PCT Pub. No. WO88/07525 PCT Pub. Date Oct. 6, 1988.Enantiomerically-pure dihydropyridines of formula I (I) are effective vasodilators useful for treating coronary diseases. They have particularly advantageous properties with regard to extent and controllability of blood pressure lowering, a surprisingly small (and for repeated administration-vanishing) increase in heart rate, excellent bioavailability, high therapeutic index, lack of central side effects, lack of kinetic interactions with other substances, absence of tolerance development, well-balanced physical properties and high stability. A new process for preparing these compounds is also presented. |
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PCT No. PCT/EP88/00239 Sec. 371 Date Sep. 19, 1989 Sec. 102(e) Date Sep. 19, 1989 PCT Filed Mar. 24, 1988 PCT Pub. No. WO88/07525 PCT Pub. Date Oct. 6, 1988.Enantiomerically-pure dihydropyridines of formula I (I) are effective vasodilators useful for treating coronary diseases. They have particularly advantageous properties with regard to extent and controllability of blood pressure lowering, a surprisingly small (and for repeated administration-vanishing) increase in heart rate, excellent bioavailability, high therapeutic index, lack of central side effects, lack of kinetic interactions with other substances, absence of tolerance development, well-balanced physical properties and high stability. A new process for preparing these compounds is also presented.</description><edition>4</edition><language>spa</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>1994</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19941116&DB=EPODOC&CC=ES&NR=2059416T3$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19941116&DB=EPODOC&CC=ES&NR=2059416T3$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>SCHUDT, CHRISTIAN</creatorcontrib><creatorcontrib>SANDERS, KARL</creatorcontrib><creatorcontrib>AMSCHLER, HERMANN</creatorcontrib><creatorcontrib>ELTZE, MANFRID</creatorcontrib><creatorcontrib>KLEMM, KURT, DR</creatorcontrib><creatorcontrib>KOLASSA, NORBERT, DR</creatorcontrib><creatorcontrib>FLOCKERZI, DIETER</creatorcontrib><creatorcontrib>EISTETTER, KLAUS</creatorcontrib><creatorcontrib>KOHL, BERNHARD</creatorcontrib><creatorcontrib>ULRICH, WOLF-RUDIGER</creatorcontrib><title>1,4-DIHIDROPIRIDINA-ENANTIOMEROS</title><description>LAS ENANTIOMEROS DE DIHIDROPIRIDINAS PUROS DE FORMULA (I) EN LA QUE LOS SUSTITUYENTES Y SIMBOLOS TIENEN EL SIGNIFICADO QUE SE INDICA EN LA DESCRIPCION SON COMPUESTOS NUEVOS CON PROPIEDADES FARMACOLOGICAS SORPRENDENTES. SE DESCRIBE UN NUEVO PROCEDIMIENTO PARA LA OBTENCION DE ESTOS COMPUESTOS.
PCT No. PCT/EP88/00239 Sec. 371 Date Sep. 19, 1989 Sec. 102(e) Date Sep. 19, 1989 PCT Filed Mar. 24, 1988 PCT Pub. No. WO88/07525 PCT Pub. Date Oct. 6, 1988.Enantiomerically-pure dihydropyridines of formula I (I) are effective vasodilators useful for treating coronary diseases. They have particularly advantageous properties with regard to extent and controllability of blood pressure lowering, a surprisingly small (and for repeated administration-vanishing) increase in heart rate, excellent bioavailability, high therapeutic index, lack of central side effects, lack of kinetic interactions with other substances, absence of tolerance development, well-balanced physical properties and high stability. A new process for preparing these compounds is also presented.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1994</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZFAw1DHRdfH08HQJ8g_wDPJ08fRz1HX1c_QL8fT3dQ3yD-ZhYE1LzClO5YXS3AyKbq4hzh66qQX58anFBYnJqXmpJfGuwUYGppYmhmYhIcbGxKgBAPS8IlE</recordid><startdate>19941116</startdate><enddate>19941116</enddate><creator>SCHUDT, CHRISTIAN</creator><creator>SANDERS, KARL</creator><creator>AMSCHLER, HERMANN</creator><creator>ELTZE, MANFRID</creator><creator>KLEMM, KURT, DR</creator><creator>KOLASSA, NORBERT, DR</creator><creator>FLOCKERZI, DIETER</creator><creator>EISTETTER, KLAUS</creator><creator>KOHL, BERNHARD</creator><creator>ULRICH, WOLF-RUDIGER</creator><scope>EVB</scope></search><sort><creationdate>19941116</creationdate><title>1,4-DIHIDROPIRIDINA-ENANTIOMEROS</title><author>SCHUDT, CHRISTIAN ; SANDERS, KARL ; AMSCHLER, HERMANN ; ELTZE, MANFRID ; KLEMM, KURT, DR ; KOLASSA, NORBERT, DR ; FLOCKERZI, DIETER ; EISTETTER, KLAUS ; KOHL, BERNHARD ; ULRICH, WOLF-RUDIGER</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_ES2059416TT33</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>spa</language><creationdate>1994</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>SCHUDT, CHRISTIAN</creatorcontrib><creatorcontrib>SANDERS, KARL</creatorcontrib><creatorcontrib>AMSCHLER, HERMANN</creatorcontrib><creatorcontrib>ELTZE, MANFRID</creatorcontrib><creatorcontrib>KLEMM, KURT, DR</creatorcontrib><creatorcontrib>KOLASSA, NORBERT, DR</creatorcontrib><creatorcontrib>FLOCKERZI, DIETER</creatorcontrib><creatorcontrib>EISTETTER, KLAUS</creatorcontrib><creatorcontrib>KOHL, BERNHARD</creatorcontrib><creatorcontrib>ULRICH, WOLF-RUDIGER</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>SCHUDT, CHRISTIAN</au><au>SANDERS, KARL</au><au>AMSCHLER, HERMANN</au><au>ELTZE, MANFRID</au><au>KLEMM, KURT, DR</au><au>KOLASSA, NORBERT, DR</au><au>FLOCKERZI, DIETER</au><au>EISTETTER, KLAUS</au><au>KOHL, BERNHARD</au><au>ULRICH, WOLF-RUDIGER</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>1,4-DIHIDROPIRIDINA-ENANTIOMEROS</title><date>1994-11-16</date><risdate>1994</risdate><abstract>LAS ENANTIOMEROS DE DIHIDROPIRIDINAS PUROS DE FORMULA (I) EN LA QUE LOS SUSTITUYENTES Y SIMBOLOS TIENEN EL SIGNIFICADO QUE SE INDICA EN LA DESCRIPCION SON COMPUESTOS NUEVOS CON PROPIEDADES FARMACOLOGICAS SORPRENDENTES. SE DESCRIBE UN NUEVO PROCEDIMIENTO PARA LA OBTENCION DE ESTOS COMPUESTOS.
PCT No. PCT/EP88/00239 Sec. 371 Date Sep. 19, 1989 Sec. 102(e) Date Sep. 19, 1989 PCT Filed Mar. 24, 1988 PCT Pub. No. WO88/07525 PCT Pub. Date Oct. 6, 1988.Enantiomerically-pure dihydropyridines of formula I (I) are effective vasodilators useful for treating coronary diseases. They have particularly advantageous properties with regard to extent and controllability of blood pressure lowering, a surprisingly small (and for repeated administration-vanishing) increase in heart rate, excellent bioavailability, high therapeutic index, lack of central side effects, lack of kinetic interactions with other substances, absence of tolerance development, well-balanced physical properties and high stability. A new process for preparing these compounds is also presented.</abstract><edition>4</edition><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | 1,4-DIHIDROPIRIDINA-ENANTIOMEROS |
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