Process for obtaining cis-4-amino-5-chloro-2-methoxy-N-[1- [3-(4-fluorophenoxy)propyl]-3-methoxy-4- piperidinyl]benzamide

Process for obtaining cis-4-amino-5-chloro-2-methoxy-N-[1- [3-(4-fluorophenoxy)propyl]-3-methoxy-4- piperidinyl]benzamide Comprises subjecting 4-[(4-amino-5-chloro-2-methoxy)- benzamido]-1-[3-(4-fluorophenoxy)propyl]-3- methoxypyridinium iodide (formula II) to a reduction process in an organic solve...

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Hauptverfasser:	CALDERO GES JOSE MARIA, HUGUET CLOTET, JUAN
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Sprache:	eng ; spa
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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creator	CALDERO GES JOSE MARIA HUGUET CLOTET, JUAN
description	Process for obtaining cis-4-amino-5-chloro-2-methoxy-N-[1- [3-(4-fluorophenoxy)propyl]-3-methoxy-4- piperidinyl]benzamide Comprises subjecting 4-[(4-amino-5-chloro-2-methoxy)- benzamido]-1-[3-(4-fluorophenoxy)propyl]-3- methoxypyridinium iodide (formula II) to a reduction process in an organic solvent using sodium borohydride as the reducing agent in the presence of particular salts of rhodium, nickel or cobalt. The product obtained, cis-4-amino-5-chloro-2-methoxy-N-[1- [3-(4-fluorophenoxy)propyl]-3-methoxy-4- piperidinyl]benzamide (formula I), has useful therapeutic properties as a gastrointestinal prokinetic agent for the treatment of gastroesophageal reflux, retarded voiding of the stomach and intestinal pseudo-obstruction. PROCEDIMIENTO PARA LA OBTENCION DE LA CIS-4-AMINO-5-CLORO-2-METOXI-N-[1-[3-(4-FLUOROFENOXI) PROPIL]-3-METOXI-4-PIPERIDINIL] BENZAMIDA. CONSISTE EN SOMETER EL YODURO DE 4-[(4-AMINO-5-CLORO-2-METOXI)-BENZAMIDO]-1-[3-(4-FLUOROFENOXI) PROPIL]-3-METOXIPIRIDINIO (FORMULA II) A UN PROCESO DE REDUCCION EN UN DISOLVENTE ORGANICO UTILIZANDO COMO AGENTE REDUCTOR BOROHIDRURO DE SODIO EN PRESENCIA DE CIERTAS SALES DE RODIO, NIQUEL O COBALTO. EL PRODUCTO OBTENIDO CIS-4-AMINO-5-CLORO-2-METOXI-N-[1-[3-(4-FLUOROFENOXI) PROPIL]-3-METOXI-4-PIPERIDINIL] BENZAMIDA (FORMULA I) TIENE INTERESANTES PROPIEDADES TERAPEUTICAS COMO AGENTE PROCINETICO GASTROINTESTINAL PARA EL TRATAMIENTO DEL REFLUJO GASTROESOFAGICO, VACIADO GASTRICO RETARDADO Y PSEUDO-OBSTRUCCION INTESTINAL.
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The product obtained, cis-4-amino-5-chloro-2-methoxy-N-[1- [3-(4-fluorophenoxy)propyl]-3-methoxy-4- piperidinyl]benzamide (formula I), has useful therapeutic properties as a gastrointestinal prokinetic agent for the treatment of gastroesophageal reflux, retarded voiding of the stomach and intestinal pseudo-obstruction. PROCEDIMIENTO PARA LA OBTENCION DE LA CIS-4-AMINO-5-CLORO-2-METOXI-N-[1-[3-(4-FLUOROFENOXI) PROPIL]-3-METOXI-4-PIPERIDINIL] BENZAMIDA. CONSISTE EN SOMETER EL YODURO DE 4-[(4-AMINO-5-CLORO-2-METOXI)-BENZAMIDO]-1-[3-(4-FLUOROFENOXI) PROPIL]-3-METOXIPIRIDINIO (FORMULA II) A UN PROCESO DE REDUCCION EN UN DISOLVENTE ORGANICO UTILIZANDO COMO AGENTE REDUCTOR BOROHIDRURO DE SODIO EN PRESENCIA DE CIERTAS SALES DE RODIO, NIQUEL O COBALTO. EL PRODUCTO OBTENIDO CIS-4-AMINO-5-CLORO-2-METOXI-N-[1-[3-(4-FLUOROFENOXI) PROPIL]-3-METOXI-4-PIPERIDINIL] BENZAMIDA (FORMULA I) TIENE INTERESANTES PROPIEDADES TERAPEUTICAS COMO AGENTE PROCINETICO GASTROINTESTINAL PARA EL TRATAMIENTO DEL REFLUJO GASTROESOFAGICO, VACIADO GASTRICO RETARDADO Y PSEUDO-OBSTRUCCION INTESTINAL.</description><edition>5</edition><language>eng ; spa</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>1991</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19910601&DB=EPODOC&CC=ES&NR=2019234A6$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,777,882,25545,76296</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19910601&DB=EPODOC&CC=ES&NR=2019234A6$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>CALDERO GES JOSE MARIA</creatorcontrib><creatorcontrib>HUGUET CLOTET, JUAN</creatorcontrib><title>Process for obtaining cis-4-amino-5-chloro-2-methoxy-N-[1- [3-(4-fluorophenoxy)propyl]-3-methoxy-4- piperidinyl]benzamide</title><description>Process for obtaining cis-4-amino-5-chloro-2-methoxy-N-[1- [3-(4-fluorophenoxy)propyl]-3-methoxy-4- piperidinyl]benzamide Comprises subjecting 4-[(4-amino-5-chloro-2-methoxy)- benzamido]-1-[3-(4-fluorophenoxy)propyl]-3- methoxypyridinium iodide (formula II) to a reduction process in an organic solvent using sodium borohydride as the reducing agent in the presence of particular salts of rhodium, nickel or cobalt. The product obtained, cis-4-amino-5-chloro-2-methoxy-N-[1- [3-(4-fluorophenoxy)propyl]-3-methoxy-4- piperidinyl]benzamide (formula I), has useful therapeutic properties as a gastrointestinal prokinetic agent for the treatment of gastroesophageal reflux, retarded voiding of the stomach and intestinal pseudo-obstruction. PROCEDIMIENTO PARA LA OBTENCION DE LA CIS-4-AMINO-5-CLORO-2-METOXI-N-[1-[3-(4-FLUOROFENOXI) PROPIL]-3-METOXI-4-PIPERIDINIL] BENZAMIDA. CONSISTE EN SOMETER EL YODURO DE 4-[(4-AMINO-5-CLORO-2-METOXI)-BENZAMIDO]-1-[3-(4-FLUOROFENOXI) PROPIL]-3-METOXIPIRIDINIO (FORMULA II) A UN PROCESO DE REDUCCION EN UN DISOLVENTE ORGANICO UTILIZANDO COMO AGENTE REDUCTOR BOROHIDRURO DE SODIO EN PRESENCIA DE CIERTAS SALES DE RODIO, NIQUEL O COBALTO. EL PRODUCTO OBTENIDO CIS-4-AMINO-5-CLORO-2-METOXI-N-[1-[3-(4-FLUOROFENOXI) PROPIL]-3-METOXI-4-PIPERIDINIL] BENZAMIDA (FORMULA I) TIENE INTERESANTES PROPIEDADES TERAPEUTICAS COMO AGENTE PROCINETICO GASTROINTESTINAL PARA EL TRATAMIENTO DEL REFLUJO GASTROESOFAGICO, VACIADO GASTRICO RETARDADO Y PSEUDO-OBSTRUCCION INTESTINAL.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1991</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNjLEKwjAURbs4iPoPGXV4YJsoOIpUnETQrUhJ0xcbSPNCUsH69WYQZ6d74BzuNBsvgRTGyDQFRs0gjTPuwZSJIED2xhFsQHWWAkEBPQ4dvUY4Q5UDqzgsBWj7TNJ36JJZ-YSjvQP_tQKYNx6DaY1LpkH3Tr8tzrOJljbi4ruzjB3L2-EE6KnG6KVCh0NdXot1viu42G_5H8kHPWlEZQ</recordid><startdate>19910601</startdate><enddate>19910601</enddate><creator>CALDERO GES JOSE MARIA</creator><creator>HUGUET CLOTET, JUAN</creator><scope>EVB</scope></search><sort><creationdate>19910601</creationdate><title>Process for obtaining cis-4-amino-5-chloro-2-methoxy-N-[1- [3-(4-fluorophenoxy)propyl]-3-methoxy-4- piperidinyl]benzamide</title><author>CALDERO GES JOSE MARIA ; HUGUET CLOTET, JUAN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_ES2019234A63</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; spa</language><creationdate>1991</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><toplevel>online_resources</toplevel><creatorcontrib>CALDERO GES JOSE MARIA</creatorcontrib><creatorcontrib>HUGUET CLOTET, JUAN</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>CALDERO GES JOSE MARIA</au><au>HUGUET CLOTET, JUAN</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Process for obtaining cis-4-amino-5-chloro-2-methoxy-N-[1- [3-(4-fluorophenoxy)propyl]-3-methoxy-4- piperidinyl]benzamide</title><date>1991-06-01</date><risdate>1991</risdate><abstract>Process for obtaining cis-4-amino-5-chloro-2-methoxy-N-[1- [3-(4-fluorophenoxy)propyl]-3-methoxy-4- piperidinyl]benzamide Comprises subjecting 4-[(4-amino-5-chloro-2-methoxy)- benzamido]-1-[3-(4-fluorophenoxy)propyl]-3- methoxypyridinium iodide (formula II) to a reduction process in an organic solvent using sodium borohydride as the reducing agent in the presence of particular salts of rhodium, nickel or cobalt. The product obtained, cis-4-amino-5-chloro-2-methoxy-N-[1- [3-(4-fluorophenoxy)propyl]-3-methoxy-4- piperidinyl]benzamide (formula I), has useful therapeutic properties as a gastrointestinal prokinetic agent for the treatment of gastroesophageal reflux, retarded voiding of the stomach and intestinal pseudo-obstruction. PROCEDIMIENTO PARA LA OBTENCION DE LA CIS-4-AMINO-5-CLORO-2-METOXI-N-[1-[3-(4-FLUOROFENOXI) PROPIL]-3-METOXI-4-PIPERIDINIL] BENZAMIDA. CONSISTE EN SOMETER EL YODURO DE 4-[(4-AMINO-5-CLORO-2-METOXI)-BENZAMIDO]-1-[3-(4-FLUOROFENOXI) PROPIL]-3-METOXIPIRIDINIO (FORMULA II) A UN PROCESO DE REDUCCION EN UN DISOLVENTE ORGANICO UTILIZANDO COMO AGENTE REDUCTOR BOROHIDRURO DE SODIO EN PRESENCIA DE CIERTAS SALES DE RODIO, NIQUEL O COBALTO. EL PRODUCTO OBTENIDO CIS-4-AMINO-5-CLORO-2-METOXI-N-[1-[3-(4-FLUOROFENOXI) PROPIL]-3-METOXI-4-PIPERIDINIL] BENZAMIDA (FORMULA I) TIENE INTERESANTES PROPIEDADES TERAPEUTICAS COMO AGENTE PROCINETICO GASTROINTESTINAL PARA EL TRATAMIENTO DEL REFLUJO GASTROESOFAGICO, VACIADO GASTRICO RETARDADO Y PSEUDO-OBSTRUCCION INTESTINAL.</abstract><edition>5</edition><oa>free_for_read</oa></addata></record>
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subjects	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
title	Process for obtaining cis-4-amino-5-chloro-2-methoxy-N-[1- [3-(4-fluorophenoxy)propyl]-3-methoxy-4- piperidinyl]benzamide
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