ANNULATED 2-AMINO-3-CYANO THIOPHENES AND DERIVATIVES FOR THE TREATMENT OF CANCER
The present invention encompasses compounds of formula (V), wherein R1a, R1b, R2a, R2b, Z, R4, R5, R14, A, p, U, V and W have the meanings given in the claims and specification, their use as inhibitors of KRAS, pharmaceutical compositions and preparations containing such compounds and their use as m...
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| creator | MANTOULIDIS, Andreas SARKAR, Dhruba LITTLE, Andrew PHAN, Jason BROEKER, Joachim SMETHURST, Christian Alan Paul SUN, Qi CUI, Jianwen WATERSON, Alex FESIK, Stephen W ABBOTT, Jason HODGES, Tim GOLLNER, Andreas |
| description | The present invention encompasses compounds of formula (V), wherein R1a, R1b, R2a, R2b, Z, R4, R5, R14, A, p, U, V and W have the meanings given in the claims and specification, their use as inhibitors of KRAS, pharmaceutical compositions and preparations containing such compounds and their use as medicaments/medical uses, especially as agents for treatment and/or prevention of oncological diseases. |
| format | Patent |
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SARKAR, Dhruba ; LITTLE, Andrew ; PHAN, Jason ; BROEKER, Joachim ; SMETHURST, Christian Alan Paul ; SUN, Qi ; CUI, Jianwen ; WATERSON, Alex ; FESIK, Stephen W ; ABBOTT, Jason ; HODGES, Tim ; GOLLNER, Andreas</creatorcontrib><description>The present invention encompasses compounds of formula (V), wherein R1a, R1b, R2a, R2b, Z, R4, R5, R14, A, p, U, V and W have the meanings given in the claims and specification, their use as inhibitors of KRAS, pharmaceutical compositions and preparations containing such compounds and their use as medicaments/medical uses, especially as agents for treatment and/or prevention of oncological diseases.</description><language>eng ; fre ; ger</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2024</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20241009&DB=EPODOC&CC=EP&NR=4441050A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20241009&DB=EPODOC&CC=EP&NR=4441050A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>MANTOULIDIS, Andreas</creatorcontrib><creatorcontrib>SARKAR, Dhruba</creatorcontrib><creatorcontrib>LITTLE, Andrew</creatorcontrib><creatorcontrib>PHAN, Jason</creatorcontrib><creatorcontrib>BROEKER, Joachim</creatorcontrib><creatorcontrib>SMETHURST, Christian Alan Paul</creatorcontrib><creatorcontrib>SUN, Qi</creatorcontrib><creatorcontrib>CUI, Jianwen</creatorcontrib><creatorcontrib>WATERSON, Alex</creatorcontrib><creatorcontrib>FESIK, Stephen W</creatorcontrib><creatorcontrib>ABBOTT, Jason</creatorcontrib><creatorcontrib>HODGES, Tim</creatorcontrib><creatorcontrib>GOLLNER, Andreas</creatorcontrib><title>ANNULATED 2-AMINO-3-CYANO THIOPHENES AND DERIVATIVES FOR THE TREATMENT OF CANCER</title><description>The present invention encompasses compounds of formula (V), wherein R1a, R1b, R2a, R2b, Z, R4, R5, R14, A, p, U, V and W have the meanings given in the claims and specification, their use as inhibitors of KRAS, pharmaceutical compositions and preparations containing such compounds and their use as medicaments/medical uses, especially as agents for treatment and/or prevention of oncological diseases.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2024</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNikEKwjAQAHPxIOof9gOB1sYHLMmGBOwmxLXgqRSJJ9FC_T_24AM8DcPMVmVkvp5RyMFRYx856U7bG3ICCTHlQEwXQHbgqMQBJQ6r-1TWTCCFUHpigeTBIlsqe7V5TM-lHn7cKfAkNug6v8e6zNO9vupnpGyMaZtTg233x_IF3gouJg</recordid><startdate>20241009</startdate><enddate>20241009</enddate><creator>MANTOULIDIS, Andreas</creator><creator>SARKAR, Dhruba</creator><creator>LITTLE, Andrew</creator><creator>PHAN, Jason</creator><creator>BROEKER, Joachim</creator><creator>SMETHURST, Christian Alan Paul</creator><creator>SUN, Qi</creator><creator>CUI, Jianwen</creator><creator>WATERSON, Alex</creator><creator>FESIK, Stephen W</creator><creator>ABBOTT, Jason</creator><creator>HODGES, Tim</creator><creator>GOLLNER, Andreas</creator><scope>EVB</scope></search><sort><creationdate>20241009</creationdate><title>ANNULATED 2-AMINO-3-CYANO THIOPHENES AND DERIVATIVES FOR THE TREATMENT OF CANCER</title><author>MANTOULIDIS, Andreas ; 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| language | eng ; fre ; ger |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | ANNULATED 2-AMINO-3-CYANO THIOPHENES AND DERIVATIVES FOR THE TREATMENT OF CANCER |
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