3-PHENYL-1-BENZOTHIOPHENE-2-CARBOXYLIC ACID DERIVATIVES AS BRANCHED-CHAIN ALPHA KETO ACID DEHYDROGENASE KINASE INHIBITORS FOR THE TREATMENT OF DIABETES, KIDNEY DISEASES, NASH AND HEART FAILURE

Described herein are compounds of Formula I,wherein the variables are defined herein, their use as branched-chain alpha keto acid dehydrogenase kinase inhibitors and/or degraders, pharmaceutical compositions containing such compounds and their use to treat, for example, diabetes, kidney disease, NAS...

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Bibliographische Detailangaben

Hauptverfasser:	ZHANG, Yuan, FILIPSKI, Kevin James, LIU, Shenping, BUZON, Leanne Marie, DEBOYACE, Kevin Francis, ROTH FLACH, Rachel Jane, KORMOS, Bethany Lyn, REESE, Matthew Richard, GRIFFITH, David Andrew, CAMERON, Kimberly O'Keefe, MARTINEZ ALSINA, Luis Angel
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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