HYALURONIDASE POLYPEPTIDE FOR USE IN THE TREATMENT OR PROPHYLAXIS OF A NEURODEGENERATIVE DISEASE

The present invention relates to a hyaluronidase peptide for use in the treatment or prophylaxis of a neurodegenerative disease and / or a dysfunctional blood-brain barrier associated with an increased cerebral glycosaminoglycan level, wherein the neurodegenerative disease is selected from Alzheimer...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	BENSON, Sven, BURGARD, Gunther, LORENZ, Lenz, SCHELLENBERGER, Philipp, BÖHNKE, Rainer
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention relates to a hyaluronidase peptide for use in the treatment or prophylaxis of a neurodegenerative disease and / or a dysfunctional blood-brain barrier associated with an increased cerebral glycosaminoglycan level, wherein the neurodegenerative disease is selected from Alzheimer's disease, vascular dementia, Parkinson's disease, multiple sclerosis, amyotrophic lateral sclerosis (ALS), cerebral insult, brain trauma, cerebral inflammations, and autoimmune encephalitis, a pharmaceutical composition for use in the treatment or prophylaxis of the neurodegenerative disease, and a method of treating subjects exhibiting the respective neurodegenerative diseases and/or dysfunctional blood-brain barrier.