MULTISPECIFIC BINDING AGENTS AGAINST PD-L1 AND CD137 IN COMBINATION

The present invention provides combination therapy using a binding agent that binds to human CD137 and to human PD-L1 in combination with a PD-1 inhibitor to reduce or prevent progression of a tumor or treating cancer.

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Bibliographische Detailangaben
Hauptverfasser:	KUZMANOV, Ivan, PENCHEVA, Nora, BLUM, Jordan, FELLERMEIER-KOPF, Sina, SAHIN, Ugur, PAULMANN, Claudia, BREIJ, Esther C. W, BECKMANN, Karsten, MUIK, Alexander, LABRIJN, Aran, HIBBERT, Richard, GARRIDO CASTRO, Patricia, DE KREUK, Bart-Jan, GIESEKE, Friedericke, GUELEN, Lars, NÜRMBERGER, Kristina, JURE-KUNKEL, Maria,N, NEIJSSEN, Joost, SCHUURMAN, Janine
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention provides combination therapy using a binding agent that binds to human CD137 and to human PD-L1 in combination with a PD-1 inhibitor to reduce or prevent progression of a tumor or treating cancer.