AN IMPROVED PROCESS FOR PURIFICATION OF PROTEIN

AN IMPROVED PROCESS FOR PURIFICATION OF PROTEIN

The present invention relates to purification process of pharmacologically active IgG1 containing protein comprising at least affinity chromatography followed by mixed-mode chromatography. The present invention provides cytotoxic T-lymphocyte-associated 4-immunoglobulin (CTLA4-Ig) fusion protein by...

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Hauptverfasser: GUPTA, Tarun Kumar, THAKKAR, Mayankkumar, NARAYAN, Om, UPADHYAY, Roshan Ganeshlal
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Sprache:eng ; fre ; ger
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CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PERFORMING OPERATIONS
PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
SEPARATION
TRANSPORTING
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creator GUPTA, Tarun Kumar
THAKKAR, Mayankkumar
NARAYAN, Om
UPADHYAY, Roshan Ganeshlal
description The present invention relates to purification process of pharmacologically active IgG1 containing protein comprising at least affinity chromatography followed by mixed-mode chromatography. The present invention provides cytotoxic T-lymphocyte-associated 4-immunoglobulin (CTLA4-Ig) fusion protein by using at least affinity chromatography, mixed-mode chromatography and optionally one or more suitable purification steps that provides purified composition of the fusion protein, substantially free of impurities selected from Pre-Peak, product and process related impurities. Further, the present invention provides highly purified CTLA4-Ig fusion protein with reduced heterogeneity.
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subjects CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PERFORMING OPERATIONS
PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
SEPARATION
TRANSPORTING
title AN IMPROVED PROCESS FOR PURIFICATION OF PROTEIN
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