ALLOSTERIC MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS

ALLOSTERIC MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS

The present disclosure relates to compounds of formula I that are useful as modulators of α 7 nAChR, compositions comprising such compounds, and the use of such compounds for preventing, treating, or ameliorating disease, particularly disorders of the central nervous system such as cognitive impairm...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: CONTRERAS, Jean-Marie, MORICE, Christophe, GARRIDO, Fabrice, WITZEL, Aurelie, BELL, Ian, M, FELLS, James, JOSEPH, Christophe, CROWLEY, Brendan, M, HUFF, Belinda, C, PAUL, Dharam, BAZZINI, Patrick
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:The present disclosure relates to compounds of formula I that are useful as modulators of α 7 nAChR, compositions comprising such compounds, and the use of such compounds for preventing, treating, or ameliorating disease, particularly disorders of the central nervous system such as cognitive impairments in Alzheimer's disease, Parkinson's disease, and schizophrenia, as well as for L-DOPA induced-dyskinesia and inflammation.