SOS1 INHIBITOR AND USE THEREOF

There is provided a novel compound of Formula I and a use thereof for the prevention or treatment of a disease associated with SOS1. In one aspect of the present invention, the novel compound is useful for the prevention or treatment of a SOS1 mediated disease such as cancer and RASopathy by inhibit...

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Hauptverfasser: HAN, Wooseok, YU, Ha Na, LIM, Sang Kyun, YOON, Kyeong Jin, KI, Dong Hyuk, SHIN, Young Sook, KIM, Donggeon, NAM, Joonwoo, KIM, Ji Eun, PARK, Dohyun, KIM, Eun-Jung, YU, Jihyun
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creator HAN, Wooseok
YU, Ha Na
LIM, Sang Kyun
YOON, Kyeong Jin
KI, Dong Hyuk
SHIN, Young Sook
KIM, Donggeon
NAM, Joonwoo
KIM, Ji Eun
PARK, Dohyun
KIM, Eun-Jung
YU, Jihyun
description There is provided a novel compound of Formula I and a use thereof for the prevention or treatment of a disease associated with SOS1. In one aspect of the present invention, the novel compound is useful for the prevention or treatment of a SOS1 mediated disease such as cancer and RASopathy by inhibiting the interaction between SOS1 and RAS family proteins or between SOS1 and RAC1.
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title SOS1 INHIBITOR AND USE THEREOF
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