SYNTHETIC IL-7 AND IL-7 IMMUNOCYTOKINES

SYNTHETIC IL-7 AND IL-7 IMMUNOCYTOKINES

The present disclosure relates to modified anti-PD-1 polypeptides linked to IL-7, pharmaceutical compositions comprising modified anti-PD-1 polypeptides linked to IL-7, methods of making anti-PD-1 polypeptides linked to IL-7, and methods of using the modified anti-PD-1 polypeptides linked to IL-7 fo...

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Hauptverfasser: ARÉVALO-RUIZ, Matilde, KREFT, Bertolt, PATTABIRAMAN, Vijaya Raghavan, MULLER, Magali, CARRALOT, Jean-Philippe, ALVAREZ SANCHEZ, Rubén
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Sprache:eng ; fre ; ger
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HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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creator ARÉVALO-RUIZ, Matilde
KREFT, Bertolt
PATTABIRAMAN, Vijaya Raghavan
MULLER, Magali
CARRALOT, Jean-Philippe
ALVAREZ SANCHEZ, Rubén
description The present disclosure relates to modified anti-PD-1 polypeptides linked to IL-7, pharmaceutical compositions comprising modified anti-PD-1 polypeptides linked to IL-7, methods of making anti-PD-1 polypeptides linked to IL-7, and methods of using the modified anti-PD-1 polypeptides linked to IL-7 for treatment of diseases. In one aspect, the disclosure relates to methods of treating cancer in a subject using the modified anti-PD-1 polypeptides linked to IL-7. Also provided herein is synthetic IL-7 and methods of manufacture thereof.
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subjects HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title SYNTHETIC IL-7 AND IL-7 IMMUNOCYTOKINES
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