POLYPEPTIDES TARGETING CD70-POSITIVE CANCERS

POLYPEPTIDES TARGETING CD70-POSITIVE CANCERS

Embodiments of the present disclosure include methods and compositions related to CD70-targeting polypeptides. In certain aspects, anti-CD70 antibodies are disclosed. In some aspects, disclosed are chimeric receptors engineered to bind to CD70. Also disclosed are immune cell engagers comprising a CD...

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Hauptverfasser: ACHARYA, Sunil, REZVANI, Katy, ENSLEY, Emily, VIEN, Long, UPRETY, Nadima, BASAR, Rafet, BOVER, Laura del Carmen
Format: Patent
Sprache:eng ; fre ; ger
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CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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creator ACHARYA, Sunil
REZVANI, Katy
ENSLEY, Emily
VIEN, Long
UPRETY, Nadima
BASAR, Rafet
BOVER, Laura del Carmen
description Embodiments of the present disclosure include methods and compositions related to CD70-targeting polypeptides. In certain aspects, anti-CD70 antibodies are disclosed. In some aspects, disclosed are chimeric receptors engineered to bind to CD70. Also disclosed are immune cell engagers comprising a CD70-binding region and one or more immune cell binding regions. Cells (e.g., NNK cells, T cells) expressing CD70-targeting peptides are described. Also described are therapeutic methods using polypeptides of the disclosure.
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subjects CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
title POLYPEPTIDES TARGETING CD70-POSITIVE CANCERS
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