IMIDAZOLO INDAZOLE COMPOUNDS AS JAK INHIBITORS

IMIDAZOLO INDAZOLE COMPOUNDS AS JAK INHIBITORS

Provided herein are compounds of formula (I):and pharmaceutically-acceptable salts thereof, where A, W, X, Y and Z are defined in the specification. The compounds of formula (I) and pharmaceutically-acceptable salts thereof are Janus kinase (JAK) inhibitors. Also provided herein are pharmaceutical c...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: DOLGONOS, Gabrielle Elaine, LAM, Tom M, OWENS, Christina, GERKEN, Philip, ALLEGRETTI, Paul, MCKINNELL, Robert Murray, SMITH, Cameron
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:Provided herein are compounds of formula (I):and pharmaceutically-acceptable salts thereof, where A, W, X, Y and Z are defined in the specification. The compounds of formula (I) and pharmaceutically-acceptable salts thereof are Janus kinase (JAK) inhibitors. Also provided herein are pharmaceutical compositions comprising such compounds; and methods of using such compounds to treat, e.g., inflammatory and fibrotic diseases, including respiratory diseases.