EXATECAN DERIVATIVES AND ANTIBODY-DRUG CONJUGATES THEREOF
Disclosed herein, in part, are compounds (I) which are exatecan derivatives with novel chemical linkers that include cathepsin B cleavable moieties, and conjugated to targeting antibodies.
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| creator | STROP, Peter PONS, Jaume VRLJIC, Marija WONG, Janica Cheuk-ying |
| description | Disclosed herein, in part, are compounds (I) which are exatecan derivatives with novel chemical linkers that include cathepsin B cleavable moieties, and conjugated to targeting antibodies. |
| format | Patent |
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| language | eng ; fre ; ger |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | EXATECAN DERIVATIVES AND ANTIBODY-DRUG CONJUGATES THEREOF |
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