PLASMA KALLIKREIN INHIBITORS

The present invention provides a compound of formula I and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing one or more disease states that could benefit from inhibition of plasma kallikrein, including hereditary angio...

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Hauptverfasser: CERNAKA, Natalija, BAO, Jianming, TANG, Haiqun, LOPEZ, Jovan Alexander, XIAO, Dong, CHENG, Alan, C, OGAWA, Anthony, K, SHARP, Phillip Patrick
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creator CERNAKA, Natalija
BAO, Jianming
TANG, Haiqun
LOPEZ, Jovan Alexander
XIAO, Dong
CHENG, Alan, C
OGAWA, Anthony, K
SHARP, Phillip Patrick
description The present invention provides a compound of formula I and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing one or more disease states that could benefit from inhibition of plasma kallikrein, including hereditary angioedema, uveitis, posterior uveitis, wet age-related macular degeneration, diabetic macular edema, diabetic retinopathy and retinal vein occlusion. The compounds are selective inhibitors of plasma kallikrein.
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title PLASMA KALLIKREIN INHIBITORS
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