STABLE DOCETAXEL ALBUMIN NANOPARTICLE COMPOSITION

STABLE DOCETAXEL ALBUMIN NANOPARTICLE COMPOSITION

A composition containing a docetaxel albumin nanoparticle. The composition contains docetaxel and an acid-denatured albumin, wherein the acid-denatured albumin is obtained by means of adding an acid to human serum albumin to adjust the pH value. The composition can be prepared into an injection or a...

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Hauptverfasser: CHEN, Dongjian, SHU, Yun, LI, Chunlei, XING, Qianbin, LI, Nan, ZHANG, Xiaojun, LIANG, Min, ZHAO, Yuanyuan
Format: Patent
Sprache:eng ; fre ; ger
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HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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creator CHEN, Dongjian
SHU, Yun
LI, Chunlei
XING, Qianbin
LI, Nan
ZHANG, Xiaojun
LIANG, Min
ZHAO, Yuanyuan
description A composition containing a docetaxel albumin nanoparticle. The composition contains docetaxel and an acid-denatured albumin, wherein the acid-denatured albumin is obtained by means of adding an acid to human serum albumin to adjust the pH value. The composition can be prepared into an injection or a freeze-dried powder injection. A composition with satisfactory physical and chemical stability is obtained by means of controlling the content of sodium octanoate in human serum albumin, preferably in an acid denaturation condition.
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subjects HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title STABLE DOCETAXEL ALBUMIN NANOPARTICLE COMPOSITION
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