TRIMERIC POLYPEPTIDES AND USES THEREOF IN THE TREATMENT OF CANCER
The invention relates to trimeric polypeptide complex comprising three monomer polypeptides wherein each monomer polypeptide comprises an anti-4-1BB specific agonistic single-chain antibody fragment (scFv), a homotrimerization domain and a polypeptide region which is capable of specifically binding...
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| creator | ÁLVAREZ VALLINA, Luis COMPTE GRAU, Marta |
| description | The invention relates to trimeric polypeptide complex comprising three monomer polypeptides wherein each monomer polypeptide comprises an anti-4-1BB specific agonistic single-chain antibody fragment (scFv), a homotrimerization domain and a polypeptide region which is capable of specifically binding to a tumor associated antigen. The invention also relates to said trimeric polypeptide complexes for use in the treatment of cancer. |
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The invention also relates to said trimeric polypeptide complexes for use in the treatment of cancer.</description><language>eng ; fre ; ger</language><subject>CHEMISTRY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PEPTIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2024</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240110&DB=EPODOC&CC=EP&NR=4301780A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25543,76293</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240110&DB=EPODOC&CC=EP&NR=4301780A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>ÁLVAREZ VALLINA, Luis</creatorcontrib><creatorcontrib>COMPTE GRAU, Marta</creatorcontrib><title>TRIMERIC POLYPEPTIDES AND USES THEREOF IN THE TREATMENT OF CANCER</title><description>The invention relates to trimeric polypeptide complex comprising three monomer polypeptides wherein each monomer polypeptide comprises an anti-4-1BB specific agonistic single-chain antibody fragment (scFv), a homotrimerization domain and a polypeptide region which is capable of specifically binding to a tumor associated antigen. The invention also relates to said trimeric polypeptide complexes for use in the treatment of cancer.</description><subject>CHEMISTRY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2024</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZHAMCfL0dQ3ydFYI8PeJDHANCPF0cQ1WcPRzUQgNBjJCPFyDXP3dFDz9QEyFkCBXxxBfV78QBaCYs6Ofs2sQDwNrWmJOcSovlOZmUHBzDXH20E0tyI9PLS5ITE7NSy2Jdw0wMTYwNLcwcDQ0JkIJAIPwKmw</recordid><startdate>20240110</startdate><enddate>20240110</enddate><creator>ÁLVAREZ VALLINA, Luis</creator><creator>COMPTE GRAU, Marta</creator><scope>EVB</scope></search><sort><creationdate>20240110</creationdate><title>TRIMERIC POLYPEPTIDES AND USES THEREOF IN THE TREATMENT OF CANCER</title><author>ÁLVAREZ VALLINA, Luis ; COMPTE GRAU, Marta</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_EP4301780A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre ; ger</language><creationdate>2024</creationdate><topic>CHEMISTRY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>ÁLVAREZ VALLINA, Luis</creatorcontrib><creatorcontrib>COMPTE GRAU, Marta</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>ÁLVAREZ VALLINA, Luis</au><au>COMPTE GRAU, Marta</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>TRIMERIC POLYPEPTIDES AND USES THEREOF IN THE TREATMENT OF CANCER</title><date>2024-01-10</date><risdate>2024</risdate><abstract>The invention relates to trimeric polypeptide complex comprising three monomer polypeptides wherein each monomer polypeptide comprises an anti-4-1BB specific agonistic single-chain antibody fragment (scFv), a homotrimerization domain and a polypeptide region which is capable of specifically binding to a tumor associated antigen. The invention also relates to said trimeric polypeptide complexes for use in the treatment of cancer.</abstract><oa>free_for_read</oa></addata></record> |
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| language | eng ; fre ; ger |
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| subjects | CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | TRIMERIC POLYPEPTIDES AND USES THEREOF IN THE TREATMENT OF CANCER |
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