GENETICALLY MODIFIED INDUCED PLURIPOTENT STEM CELLS AND METHODS OF USE THEREOF

Disclosed are methods and compositions for obtaining modified induced pluripotent stem cells (iPSCs) and derivative cells with stable and functional genetic modifications at selected sites. Also provided are cell populations or clonally differentiated cell derived from modified iPSCs, which comprise...

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Hauptverfasser:	MADISON, Blair, MARTIN, Renata, XI, Haibin
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Disclosed are methods and compositions for obtaining modified induced pluripotent stem cells (iPSCs) and derivative cells with stable and functional genetic modifications at selected sites. Also provided are cell populations or clonally differentiated cell derived from modified iPSCs, which comprise targeted integration of one or more exogenous polynucleotides, and/or indels in one or more selected gene loci.