ADENOVIRUS ARMED WITH BISPECIFIC T CELL ENGAGER (BITE)

A modified adenovirus, in particular Enadenotucirev (EnAd), armed with a bispecific T cell engager comprising at least two binding domains, wherein at least one of the domains is specific for a surface antigen on a T-cell of interest Also provided are a composition, such as a pharmaceutical formulat...

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Hauptverfasser:	SEYMOUR, Leonard William, BROMLEY, Alice Claire Noel, FREEDMAN, Joshua, David, FISHER, Kerry, David, CHAMPION, Brian
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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creator	SEYMOUR, Leonard William BROMLEY, Alice Claire Noel FREEDMAN, Joshua, David FISHER, Kerry, David CHAMPION, Brian
description	A modified adenovirus, in particular Enadenotucirev (EnAd), armed with a bispecific T cell engager comprising at least two binding domains, wherein at least one of the domains is specific for a surface antigen on a T-cell of interest Also provided are a composition, such as a pharmaceutical formulation comprising the virus, use of the virus and virus formulations for treatment, such as in the treatment of cancer. The disclosure also extends to processes for preparing the virus.
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subjects	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
title	ADENOVIRUS ARMED WITH BISPECIFIC T CELL ENGAGER (BITE)
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