VARIABLE HEAVY CHAIN ONLY LIBRARIES, METHODS OF PREPARATION THEREOF, AND USES THEREOF

The present disclosure relates to designs and applications of Variable Heavy Only (VHO) domain regions. The present disclosure provides a VHO library of polynucleotides encoding VHO domains, wherein the VHO domains are designed based on the Vh domain of a human Vh family, and a method of generating...

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Hauptverfasser:	WHITAKER, Brian, FUNG, Man-Cheong, TORNETTA, Mark Anthony, CHIU, Mark
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	CHEMISTRY COMBINATORIAL CHEMISTRY LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICOLIBRARIES METALLURGY ORGANIC CHEMISTRY PEPTIDES
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creator	WHITAKER, Brian FUNG, Man-Cheong TORNETTA, Mark Anthony CHIU, Mark
description	The present disclosure relates to designs and applications of Variable Heavy Only (VHO) domain regions. The present disclosure provides a VHO library of polynucleotides encoding VHO domains, wherein the VHO domains are designed based on the Vh domain of a human Vh family, and a method of generating the VHO library. The present disclosure also provides a phage library displaying the VHO domains encoded by the VHO library through the use of M13 bacteriophage minor coat proteins such as pIX and pVII and a method of generating the phage library. The present disclosure also provides a method of screening the phage library to identify VHO candidates that are capable of binding a target of interest.
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subjects	CHEMISTRY COMBINATORIAL CHEMISTRY LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICOLIBRARIES METALLURGY ORGANIC CHEMISTRY PEPTIDES
title	VARIABLE HEAVY CHAIN ONLY LIBRARIES, METHODS OF PREPARATION THEREOF, AND USES THEREOF
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