COMBINED GENE AND RADIO THERAPY FOR THE TREATMENT OF CANCER
The invention relates to an expression system comprising a first and/or a second nucleic acid construct, particularly for use in a combined gene and radiation therapy for the treatment of diseases, especially cancer. The first nucleic acid construct encodes for a target STING, that is responsive to...
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| creator | PRIETO VALTUEÑA, Jesus M GOULD, David James HONORATO CÍA, Beatriz MARCO MARTÍNEZ, Sonia TENESACA CAYAMBE, Shirley Mireya |
| description | The invention relates to an expression system comprising a first and/or a second nucleic acid construct, particularly for use in a combined gene and radiation therapy for the treatment of diseases, especially cancer. The first nucleic acid construct encodes for a target STING, that is responsive to a STING agonist recognizing said target STING but not the human STING and natural variants thereof, wherein said sequence encoding the target STING is operatively linked to elements allowing expression and/or translation of said target STING. The second nucleic acid construct comprise a therapeutic gene sequence which is operatively linked to a STING responsive promoter. Said expression system is administered to a target tissue or organ that received prior low dose radiation and is followed by another round of radiation therapy and/or treatment with a STING agonist. |
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The first nucleic acid construct encodes for a target STING, that is responsive to a STING agonist recognizing said target STING but not the human STING and natural variants thereof, wherein said sequence encoding the target STING is operatively linked to elements allowing expression and/or translation of said target STING. The second nucleic acid construct comprise a therapeutic gene sequence which is operatively linked to a STING responsive promoter. Said expression system is administered to a target tissue or organ that received prior low dose radiation and is followed by another round of radiation therapy and/or treatment with a STING agonist.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| title | COMBINED GENE AND RADIO THERAPY FOR THE TREATMENT OF CANCER |
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