BIOREACTOR PRODUCTION OF VIRUS FROM ADHERENT CELLS

Methods for producing viruses from adherent cells are provided. The methods include releasing virus from adherent host cells grown in a bioreactor, and purifying released virus by ultrafiltration and/or diafiltration. The methods can be used to manufacture viruses, including for clinical use, at red...

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Bibliographische Detailangaben
Hauptverfasser: AGUILAR, Richard, J, CAPPELLO, Joseph
Format: Patent
Sprache:eng ; fre ; ger
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Zusammenfassung:Methods for producing viruses from adherent cells are provided. The methods include releasing virus from adherent host cells grown in a bioreactor, and purifying released virus by ultrafiltration and/or diafiltration. The methods can be used to manufacture viruses, including for clinical use, at reduced cost relative to conventional virus manufacturing methods.