INOTODIOL AS AGONIST OF LIVER X RECEPTORS, AND USE THEREOF

The present disclosure relates to inotodiol as a liver X receptor agonist and use thereof for the treatment of a liver X receptor-mediated disease. Inotodiol according to an aspect, or a prodrug thereof has LXRβ-specific agonist activity, and thus not only has remarkable safety compared to other LXR...

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Hauptverfasser:	PARK, Hyunah, LEE, Wonhee, LEE, Chang Kyu, LEE, Nan Young, BAN, So Young, PARK, Kyubeen
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	FOODS OR FOODSTUFFS FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPECIFIC USE OF COSMETICS OR SIMILAR TOILETPREPARATIONS THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
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creator	PARK, Hyunah LEE, Wonhee LEE, Chang Kyu LEE, Nan Young BAN, So Young PARK, Kyubeen
description	The present disclosure relates to inotodiol as a liver X receptor agonist and use thereof for the treatment of a liver X receptor-mediated disease. Inotodiol according to an aspect, or a prodrug thereof has LXRβ-specific agonist activity, and thus not only has remarkable safety compared to other LXR agonists, but can also be effectively used in the treatment of LXR-related diseases, such as a neurodegenerative brain disease, an autoimmune disease, NASH, and NAFLD.
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subjects	FOODS OR FOODSTUFFS FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPECIFIC USE OF COSMETICS OR SIMILAR TOILETPREPARATIONS THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
title	INOTODIOL AS AGONIST OF LIVER X RECEPTORS, AND USE THEREOF
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