COMPOSITION CONTAINING ARYLAMIDE DERIVATIVE

The present disclosure provides, for example, a composition comprising:2-(4-cyclopropyl-2-fluoroanilino)-3,4-difluoro-5-[[3-fluoro-2-(methylsu lfamoylamino)pyridin-4-yl]methyl]benzamide or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate of said compound or salt;...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: KANOH Takeo, NAKAE Shinichi
Format: Patent
Sprache:eng ; fre ; ger
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Zusammenfassung:The present disclosure provides, for example, a composition comprising:2-(4-cyclopropyl-2-fluoroanilino)-3,4-difluoro-5-[[3-fluoro-2-(methylsu lfamoylamino)pyridin-4-yl]methyl]benzamide or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate of said compound or salt; and a dispersant (e.g., methylcellulose) and/or a basic compound (e.g., meglumine). According to the present disclosure, there is provided a composition comprising a specific aryl amide derivative that has RAF/MEK complex-stabilizing activity and/or MEK-inhibiting activity and is useful for the treatment or prevention of a cell proliferative disorder, particularly a cancer, the composition having good properties with respect to the dissolution and/or stability of the aryl amide derivative in the composition.