ACTIVATION OF BIOLUMINESCENCE BY STRUCTURAL COMPLEMENTATION

ACTIVATION OF BIOLUMINESCENCE BY STRUCTURAL COMPLEMENTATION

Provided herein are compositions and methods for the assembly of a bioluminescent complex from two or more non-luminescent (e.g., substantially non-luminescent) peptide and/or polypeptide units. In particular, bioluminescent activity is conferred upon a non-luminescent polypeptide via structural com...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Dart, Melanie, Goueli, Said, Unch, James, Dixon, Andrew S, Encell, Lance, Schwinn, Marie, Mondal, Subhanjan, Meisenheimer, Poncho, Robers, Matthew, Machleidt, Thomas, Nath, Nidhi, Binkowski, Brock F, Wood, Monika, Kirkland, Thomas, Hall, Mary, Zegzouti, Hicham, Pulukkunat, Dileep K, Wood, Keith
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PHYSICS
TESTING
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Beschreibung
Zusammenfassung:Provided herein are compositions and methods for the assembly of a bioluminescent complex from two or more non-luminescent (e.g., substantially non-luminescent) peptide and/or polypeptide units. In particular, bioluminescent activity is conferred upon a non-luminescent polypeptide via structural complementation with another, complementary non-luminescent peptide.