INJECTABLE COMPOSITION COMPRISING GNRH DERIVATIVES
An injectable composition of the present invention has remarkably increased safety by forming, into a composition, a sorbitan unsaturated fatty acid ester comprising g a polar head group with two or more -OH (hydroxyl) groups, is in a liquid phase in a phase where an aqueous fluid is absent so as to...
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creator | NOH, Sang Myoung LIM, Jong Lae JUNG, Sung Bum KO, Jin Young |
description | An injectable composition of the present invention has remarkably increased safety by forming, into a composition, a sorbitan unsaturated fatty acid ester comprising g a polar head group with two or more -OH (hydroxyl) groups, is in a liquid phase in a phase where an aqueous fluid is absent so as to be easily applied to pharmaceutical preparations in dosage forms, and forms a liquid crystal in an aqueous fluid phase so that sustained-release effects of GnRH analogue, which is used as a pharmaceutically active substance in vivo, are exhibited. In addition, in an injectable composition of the present invention, a sustained-release lipid initial preparation comprising GnRH analogue includes water, and thus a liquid injectable agent forms a liquid crystal gel immediately after administration, so that the effects of reducing initial release rate and remarkably increasing sustained-release properties of the drug are exhibited. |
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In addition, in an injectable composition of the present invention, a sustained-release lipid initial preparation comprising GnRH analogue includes water, and thus a liquid injectable agent forms a liquid crystal gel immediately after administration, so that the effects of reducing initial release rate and remarkably increasing sustained-release properties of the drug are exhibited.</description><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2024</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZDDy9PNydQ5xdPJxVXD29w3wD_YM8fT3A7ODPIM9_dwV3P2CPBRcXIM8wxxDPMNcg3kYWNMSc4pTeaE0N4OCm2uIs4duakF-fGpxQWJyal5qSbxrgImhubGZoYmjiTERSgBWQibQ</recordid><startdate>20240814</startdate><enddate>20240814</enddate><creator>NOH, Sang Myoung</creator><creator>LIM, Jong Lae</creator><creator>JUNG, Sung Bum</creator><creator>KO, Jin Young</creator><scope>EVB</scope></search><sort><creationdate>20240814</creationdate><title>INJECTABLE COMPOSITION COMPRISING GNRH DERIVATIVES</title><author>NOH, Sang Myoung ; LIM, Jong Lae ; JUNG, Sung Bum ; KO, Jin Young</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_EP4173614A43</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre ; ger</language><creationdate>2024</creationdate><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>NOH, Sang Myoung</creatorcontrib><creatorcontrib>LIM, Jong Lae</creatorcontrib><creatorcontrib>JUNG, Sung Bum</creatorcontrib><creatorcontrib>KO, Jin Young</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>NOH, Sang Myoung</au><au>LIM, Jong Lae</au><au>JUNG, Sung Bum</au><au>KO, Jin Young</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>INJECTABLE COMPOSITION COMPRISING GNRH DERIVATIVES</title><date>2024-08-14</date><risdate>2024</risdate><abstract>An injectable composition of the present invention has remarkably increased safety by forming, into a composition, a sorbitan unsaturated fatty acid ester comprising g a polar head group with two or more -OH (hydroxyl) groups, is in a liquid phase in a phase where an aqueous fluid is absent so as to be easily applied to pharmaceutical preparations in dosage forms, and forms a liquid crystal in an aqueous fluid phase so that sustained-release effects of GnRH analogue, which is used as a pharmaceutically active substance in vivo, are exhibited. In addition, in an injectable composition of the present invention, a sustained-release lipid initial preparation comprising GnRH analogue includes water, and thus a liquid injectable agent forms a liquid crystal gel immediately after administration, so that the effects of reducing initial release rate and remarkably increasing sustained-release properties of the drug are exhibited.</abstract><oa>free_for_read</oa></addata></record> |
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subjects | HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
title | INJECTABLE COMPOSITION COMPRISING GNRH DERIVATIVES |
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