5-OXOPYRROLIDINE-3-CARBOXAMIDES AS NAV1.8 INHIBITORS

5-OXOPYRROLIDINE-3-CARBOXAMIDES AS NAV1.8 INHIBITORS

Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are inhibitors of Nav1.8 channel activity and may be useful in the treatment, prevention, management, amelioration, control and suppression of diseases mediated by Nav1.8 channel activity. The compounds...

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Hauptverfasser: BELL, Ian, M, SHAH, Akshay, A, LAYTON, Mark, E, KELLY, Michael, J., III, COX, Jason, M, LIU, Hong, LIU, Jian, ARASAPPAN, Ashok, VANHEYST, Michael, D
Format: Patent
Sprache:eng ; fre ; ger
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HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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creator BELL, Ian, M
SHAH, Akshay, A
LAYTON, Mark, E
KELLY, Michael, J., III
COX, Jason, M
LIU, Hong
LIU, Jian
ARASAPPAN, Ashok
VANHEYST, Michael, D
description Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are inhibitors of Nav1.8 channel activity and may be useful in the treatment, prevention, management, amelioration, control and suppression of diseases mediated by Nav1.8 channel activity. The compounds of the present invention may be useful in the treatment, prevention or management of pain disorders, cough disorders, acute itch disorders, and chronic itch disorders.
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subjects HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
title 5-OXOPYRROLIDINE-3-CARBOXAMIDES AS NAV1.8 INHIBITORS
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