ARRAYS AND METHODS FOR IDENTIFYING BINDING SITES ON A PROTEIN
A method of identifying of amino-acid residues on a target protein that form a binding site of a molecule of interest. Such method relies on selection of relevant patches of solvent-accessible residues and testing of an array of mutated proteins for changes of binding properties. Such method is usef...
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| creator | LIGHTWOOD, Daniel John SPILIOTOPOULOS, Anastasios KELM, Sebastian MCMILLAN, David, James WRIGHT, Michael John LIU, Xiaofeng |
| description | A method of identifying of amino-acid residues on a target protein that form a binding site of a molecule of interest. Such method relies on selection of relevant patches of solvent-accessible residues and testing of an array of mutated proteins for changes of binding properties. Such method is useful for determining binding sites (epitopes) of antibodies, ligands and related molecules. |
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| subjects | CHEMISTRY COMBINATORIAL CHEMISTRY INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICOLIBRARIES MEASURING METALLURGY PHYSICS TESTING |
| title | ARRAYS AND METHODS FOR IDENTIFYING BINDING SITES ON A PROTEIN |
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