PEPTIDE FOR THE TREATMENT OF CYTOKINE STORM SYNDROME
Pharmaceutical composition comprising the APL-type peptide identified as SEQ ID NO: 1, as an inhibitor of a state of hyperinflammation characterized by an increase in cytokines or interleukins and inflammatory molecules, which increase their concentration until reaching the state defined as "cy...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , |
|---|---|
| Format: | Patent |
| Sprache: | eng ; fre ; ger |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | NODARSE CUNI, Hugo ORTEGA GONZÁLEZ, Lilia, María VENEGAS RODRIGUEZ, Rafael GARAY PEREZ, Hilda, Elisa MARTINEZ DONATO, Gillian DOMÍNGUEZ HORTA, María del Carmen HERNÁNDEZ CEDEÑO, Mabel LOPEZ ABAD, Cruz Matilde UBIETA GÓMEZ, Raimundo GUILLEN NIETO, Gerardo, Enrique |
| description | Pharmaceutical composition comprising the APL-type peptide identified as SEQ ID NO: 1, as an inhibitor of a state of hyperinflammation characterized by an increase in cytokines or interleukins and inflammatory molecules, which increase their concentration until reaching the state defined as "cytokine storm". The sucrose concentrations in said composition increase the biological activity of the peptide, facilitating its intravenous application. Said peptide in a pharmaceutical composition is useful for the manufacture of a drug to treat diseases related to hyperinflammation, such as Covid-19, dengue, macrophage activation syndrome, respiratory sepsis and chimeric antigen receptor T-Cell therapies, and acute respiratory distress syndrome. It also discloses a method for the treatment of said diseases, administering a therapeutically effective amount of the composition. |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_EP4137144A2</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>EP4137144A2</sourcerecordid><originalsourceid>FETCH-epo_espacenet_EP4137144A23</originalsourceid><addsrcrecordid>eNrjZDAJcA0I8XRxVXDzD1II8XBVCAlydQzxdfULUfB3U3CODPH39vRzVQgO8Q_yVQiO9HMJ8vd15WFgTUvMKU7lhdLcDApuriHOHrqpBfnxqcUFicmpeakl8a4BJobG5oYmJo5GxkQoAQCGvicd</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>PEPTIDE FOR THE TREATMENT OF CYTOKINE STORM SYNDROME</title><source>esp@cenet</source><creator>NODARSE CUNI, Hugo ; ORTEGA GONZÁLEZ, Lilia, María ; VENEGAS RODRIGUEZ, Rafael ; GARAY PEREZ, Hilda, Elisa ; MARTINEZ DONATO, Gillian ; DOMÍNGUEZ HORTA, María del Carmen ; HERNÁNDEZ CEDEÑO, Mabel ; LOPEZ ABAD, Cruz Matilde ; UBIETA GÓMEZ, Raimundo ; GUILLEN NIETO, Gerardo, Enrique</creator><creatorcontrib>NODARSE CUNI, Hugo ; ORTEGA GONZÁLEZ, Lilia, María ; VENEGAS RODRIGUEZ, Rafael ; GARAY PEREZ, Hilda, Elisa ; MARTINEZ DONATO, Gillian ; DOMÍNGUEZ HORTA, María del Carmen ; HERNÁNDEZ CEDEÑO, Mabel ; LOPEZ ABAD, Cruz Matilde ; UBIETA GÓMEZ, Raimundo ; GUILLEN NIETO, Gerardo, Enrique</creatorcontrib><description>Pharmaceutical composition comprising the APL-type peptide identified as SEQ ID NO: 1, as an inhibitor of a state of hyperinflammation characterized by an increase in cytokines or interleukins and inflammatory molecules, which increase their concentration until reaching the state defined as "cytokine storm". The sucrose concentrations in said composition increase the biological activity of the peptide, facilitating its intravenous application. Said peptide in a pharmaceutical composition is useful for the manufacture of a drug to treat diseases related to hyperinflammation, such as Covid-19, dengue, macrophage activation syndrome, respiratory sepsis and chimeric antigen receptor T-Cell therapies, and acute respiratory distress syndrome. It also discloses a method for the treatment of said diseases, administering a therapeutically effective amount of the composition.</description><language>eng ; fre ; ger</language><subject>HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2023</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230222&DB=EPODOC&CC=EP&NR=4137144A2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25543,76294</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230222&DB=EPODOC&CC=EP&NR=4137144A2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>NODARSE CUNI, Hugo</creatorcontrib><creatorcontrib>ORTEGA GONZÁLEZ, Lilia, María</creatorcontrib><creatorcontrib>VENEGAS RODRIGUEZ, Rafael</creatorcontrib><creatorcontrib>GARAY PEREZ, Hilda, Elisa</creatorcontrib><creatorcontrib>MARTINEZ DONATO, Gillian</creatorcontrib><creatorcontrib>DOMÍNGUEZ HORTA, María del Carmen</creatorcontrib><creatorcontrib>HERNÁNDEZ CEDEÑO, Mabel</creatorcontrib><creatorcontrib>LOPEZ ABAD, Cruz Matilde</creatorcontrib><creatorcontrib>UBIETA GÓMEZ, Raimundo</creatorcontrib><creatorcontrib>GUILLEN NIETO, Gerardo, Enrique</creatorcontrib><title>PEPTIDE FOR THE TREATMENT OF CYTOKINE STORM SYNDROME</title><description>Pharmaceutical composition comprising the APL-type peptide identified as SEQ ID NO: 1, as an inhibitor of a state of hyperinflammation characterized by an increase in cytokines or interleukins and inflammatory molecules, which increase their concentration until reaching the state defined as "cytokine storm". The sucrose concentrations in said composition increase the biological activity of the peptide, facilitating its intravenous application. Said peptide in a pharmaceutical composition is useful for the manufacture of a drug to treat diseases related to hyperinflammation, such as Covid-19, dengue, macrophage activation syndrome, respiratory sepsis and chimeric antigen receptor T-Cell therapies, and acute respiratory distress syndrome. It also discloses a method for the treatment of said diseases, administering a therapeutically effective amount of the composition.</description><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2023</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZDAJcA0I8XRxVXDzD1II8XBVCAlydQzxdfULUfB3U3CODPH39vRzVQgO8Q_yVQiO9HMJ8vd15WFgTUvMKU7lhdLcDApuriHOHrqpBfnxqcUFicmpeakl8a4BJobG5oYmJo5GxkQoAQCGvicd</recordid><startdate>20230222</startdate><enddate>20230222</enddate><creator>NODARSE CUNI, Hugo</creator><creator>ORTEGA GONZÁLEZ, Lilia, María</creator><creator>VENEGAS RODRIGUEZ, Rafael</creator><creator>GARAY PEREZ, Hilda, Elisa</creator><creator>MARTINEZ DONATO, Gillian</creator><creator>DOMÍNGUEZ HORTA, María del Carmen</creator><creator>HERNÁNDEZ CEDEÑO, Mabel</creator><creator>LOPEZ ABAD, Cruz Matilde</creator><creator>UBIETA GÓMEZ, Raimundo</creator><creator>GUILLEN NIETO, Gerardo, Enrique</creator><scope>EVB</scope></search><sort><creationdate>20230222</creationdate><title>PEPTIDE FOR THE TREATMENT OF CYTOKINE STORM SYNDROME</title><author>NODARSE CUNI, Hugo ; ORTEGA GONZÁLEZ, Lilia, María ; VENEGAS RODRIGUEZ, Rafael ; GARAY PEREZ, Hilda, Elisa ; MARTINEZ DONATO, Gillian ; DOMÍNGUEZ HORTA, María del Carmen ; HERNÁNDEZ CEDEÑO, Mabel ; LOPEZ ABAD, Cruz Matilde ; UBIETA GÓMEZ, Raimundo ; GUILLEN NIETO, Gerardo, Enrique</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_EP4137144A23</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre ; ger</language><creationdate>2023</creationdate><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>NODARSE CUNI, Hugo</creatorcontrib><creatorcontrib>ORTEGA GONZÁLEZ, Lilia, María</creatorcontrib><creatorcontrib>VENEGAS RODRIGUEZ, Rafael</creatorcontrib><creatorcontrib>GARAY PEREZ, Hilda, Elisa</creatorcontrib><creatorcontrib>MARTINEZ DONATO, Gillian</creatorcontrib><creatorcontrib>DOMÍNGUEZ HORTA, María del Carmen</creatorcontrib><creatorcontrib>HERNÁNDEZ CEDEÑO, Mabel</creatorcontrib><creatorcontrib>LOPEZ ABAD, Cruz Matilde</creatorcontrib><creatorcontrib>UBIETA GÓMEZ, Raimundo</creatorcontrib><creatorcontrib>GUILLEN NIETO, Gerardo, Enrique</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>NODARSE CUNI, Hugo</au><au>ORTEGA GONZÁLEZ, Lilia, María</au><au>VENEGAS RODRIGUEZ, Rafael</au><au>GARAY PEREZ, Hilda, Elisa</au><au>MARTINEZ DONATO, Gillian</au><au>DOMÍNGUEZ HORTA, María del Carmen</au><au>HERNÁNDEZ CEDEÑO, Mabel</au><au>LOPEZ ABAD, Cruz Matilde</au><au>UBIETA GÓMEZ, Raimundo</au><au>GUILLEN NIETO, Gerardo, Enrique</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>PEPTIDE FOR THE TREATMENT OF CYTOKINE STORM SYNDROME</title><date>2023-02-22</date><risdate>2023</risdate><abstract>Pharmaceutical composition comprising the APL-type peptide identified as SEQ ID NO: 1, as an inhibitor of a state of hyperinflammation characterized by an increase in cytokines or interleukins and inflammatory molecules, which increase their concentration until reaching the state defined as "cytokine storm". The sucrose concentrations in said composition increase the biological activity of the peptide, facilitating its intravenous application. Said peptide in a pharmaceutical composition is useful for the manufacture of a drug to treat diseases related to hyperinflammation, such as Covid-19, dengue, macrophage activation syndrome, respiratory sepsis and chimeric antigen receptor T-Cell therapies, and acute respiratory distress syndrome. It also discloses a method for the treatment of said diseases, administering a therapeutically effective amount of the composition.</abstract><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | eng ; fre ; ger |
| recordid | cdi_epo_espacenet_EP4137144A2 |
| source | esp@cenet |
| subjects | HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | PEPTIDE FOR THE TREATMENT OF CYTOKINE STORM SYNDROME |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-22T05%3A34%3A24IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=NODARSE%20CUNI,%20Hugo&rft.date=2023-02-22&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EEP4137144A2%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |