SUBSTITUTED PYRIDAZINE COMPOUND

The object of the present invention is to provide a pharmaceutical composition, in particular, a compound suitable for prevention and/or treatment of an inflammatory disease and/or a neurodegenerative disease. The present inventors have extensively conducted studies for discovering a compound having...

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Bibliographische Detailangaben
Hauptverfasser:	NEGORO, Kenji, SABA, Kengo, IIDA, Maiko, KOIZUMI, Yuka, YAMAKI, Susumu, INAGAKI, Yusuke, KOIKE, Takanori, MAEDA, Junko, KAMIKUBO, Takashi, NIGAWARA, Takahiro, KURIWAKI, Ikumi, SHISHIKURA, Junichi
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The object of the present invention is to provide a pharmaceutical composition, in particular, a compound suitable for prevention and/or treatment of an inflammatory disease and/or a neurodegenerative disease. The present inventors have extensively conducted studies for discovering a compound having an inhibitory action on NLRP3 inflammasome activation, and found that substituted pyridazine compound has an inhibitory action on NLRP3 inflammasome activation. In this way, the present invention has been attained. The substituted pyridazine compound of the present invention is expected to serve as a prophylactic and/or therapeutic drug for an inflammatory disease and/or a neurodegenerative disease.