SUBSTITUTED FURO[3,2-D]PYRIMIDINES AND USES THEREOF

SUBSTITUTED FURO[3,2-D]PYRIMIDINES AND USES THEREOF

The present disclosure provides compounds that are inhibitors of PIKfyve and/or PI3 kinases, and are therefore useful for the treatment of neurological diseases treatable by inhibition of PIKfyve and/or PI3 kinases. Also provided are pharmaceutical compositions containing such compounds, and methods...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: KOPEC, Brian, CHOI, Irene Y, GALEMMO, Robert A., JR, RHODES, Jane, ROSEN, Mark D, LIANG, Weiling
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The present disclosure provides compounds that are inhibitors of PIKfyve and/or PI3 kinases, and are therefore useful for the treatment of neurological diseases treatable by inhibition of PIKfyve and/or PI3 kinases. Also provided are pharmaceutical compositions containing such compounds, and methods of treatment of neurological diseases using such compounds.