METHODS AND COMPOSITIONS FOR PREVENTING ADSORPTION OF THERAPEUTIC PROTEINS TO DRUG DELIVERY SYSTEM COMPONENTS

METHODS AND COMPOSITIONS FOR PREVENTING ADSORPTION OF THERAPEUTIC PROTEINS TO DRUG DELIVERY SYSTEM COMPONENTS

The disclosure provides compositions and methods that reduce protein loss during drug delivery due to adsorption of the protein onto one or more components of a drug delivery system. In some embodiments, the disclosure provides a composition for preventing protein adsorption to one or more component...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: LI, Gang, CLAPPER, Jonathan, WEE, Siowfong
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:The disclosure provides compositions and methods that reduce protein loss during drug delivery due to adsorption of the protein onto one or more components of a drug delivery system. In some embodiments, the disclosure provides a composition for preventing protein adsorption to one or more components of a drug delivery system, the composition comprising succinate and polysorbate 80. In some embodiments, the composition further comprises a therapeutic protein.