PREPARATION METHOD OF QUINOLINE DERIVATIVE COMPOUNDS

PREPARATION METHOD OF QUINOLINE DERIVATIVE COMPOUNDS

The present invention relates to a method for preparing a compound of formula (I) comprising the following steps: (i) reacting a compound of formula (II) with a compound of formula (III), to form the hydrochloride salt of the compound of formula (I), wherein the molar ratio of the compound of formul...

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Hauptverfasser: DENIS, Jérôme, GUERIN, Charles, MICHAUX, Julien, NAJMAN, Romain, BOYER, Thierry, DE BLASIO, Fabien, MAHUTEAU-BETZER, Florence
Format: Patent
Sprache:eng ; fre ; ger
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CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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creator DENIS, Jérôme
GUERIN, Charles
MICHAUX, Julien
NAJMAN, Romain
BOYER, Thierry
DE BLASIO, Fabien
MAHUTEAU-BETZER, Florence
description The present invention relates to a method for preparing a compound of formula (I) comprising the following steps: (i) reacting a compound of formula (II) with a compound of formula (III), to form the hydrochloride salt of the compound of formula (I), wherein the molar ratio of the compound of formula (II) vs. the compound of formula (III) is from 1.00:0.80 to 1.00:1.20, and no metal catalyst is present, and (ii) recovering the compound of formula (I) in the form of a free base through addition of a base.
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
title PREPARATION METHOD OF QUINOLINE DERIVATIVE COMPOUNDS
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