METHOD FOR SELECTIVELY KILLING PROTEIN AGGREGATE-CONTAINING CELLS, KIT THEREFOR, THERAPEUTIC DRUG FOR PROTEIN MISFOLDING DISEASES AND DRUG PRODUCT FOR REMOVING PROTEIN AGGREGATES FROM BLOOD PRODUCT

METHOD FOR SELECTIVELY KILLING PROTEIN AGGREGATE-CONTAINING CELLS, KIT THEREFOR, THERAPEUTIC DRUG FOR PROTEIN MISFOLDING DISEASES AND DRUG PRODUCT FOR REMOVING PROTEIN AGGREGATES FROM BLOOD PRODUCT

A method for selectively killing protein aggregate-containing cells, a kit thereof, a therapeutic agent for the protein misfolding disease, and an agent for removing a protein aggregate from a blood derivative are provided. The method for selectively killing cells according to one embodiment acts a...

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1. Verfasser: OGAWA Tsuyoshi
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Sprache:eng ; fre ; ger
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HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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description A method for selectively killing protein aggregate-containing cells, a kit thereof, a therapeutic agent for the protein misfolding disease, and an agent for removing a protein aggregate from a blood derivative are provided. The method for selectively killing cells according to one embodiment acts a fluorine-based alcohol or a compound represented by general formula (1) on cells as a compound for detecting a protein aggregate and selectively kills protein aggregate-containing cells.(in general formula (1), a is 0 or 1,when a is 1, then R1 is a hydrogen atom and R2 is a hydroxyl group, or R1 is a hydroxyl group and R2 is a hydrogen atom, when a is 0, then R2 is an oxygen atom forming a double bond together with a carbon atom, R3 is CHlClmFn, and I is an integer from 0 to 3, m and n are integers from 1 to 3, and I + m + n = 3 is satisfied, R4 is CHsCltFu, and s is an integer from 0 to 3, t and u are integers from 1 to 3, and s + t + u = 3 is satisfied. I + s < 6 is satisfied.)
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The method for selectively killing cells according to one embodiment acts a fluorine-based alcohol or a compound represented by general formula (1) on cells as a compound for detecting a protein aggregate and selectively kills protein aggregate-containing cells.(in general formula (1), a is 0 or 1,when a is 1, then R1 is a hydrogen atom and R2 is a hydroxyl group, or R1 is a hydroxyl group and R2 is a hydrogen atom, when a is 0, then R2 is an oxygen atom forming a double bond together with a carbon atom, R3 is CHlClmFn, and I is an integer from 0 to 3, m and n are integers from 1 to 3, and I + m + n = 3 is satisfied, R4 is CHsCltFu, and s is an integer from 0 to 3, t and u are integers from 1 to 3, and s + t + u = 3 is satisfied. 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subjects HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title METHOD FOR SELECTIVELY KILLING PROTEIN AGGREGATE-CONTAINING CELLS, KIT THEREFOR, THERAPEUTIC DRUG FOR PROTEIN MISFOLDING DISEASES AND DRUG PRODUCT FOR REMOVING PROTEIN AGGREGATES FROM BLOOD PRODUCT
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