EP300/CBP INHIBITOR
An EP300/CBP inhibitor; specifically provided is a compound as shown in formula I, or a deuterated product thereof, or a salt thereof, or a conformational isomer thereof, or a crystal form thereof, or a solvate thereof. The compound is highly selective for EP300/CBP, and can effectively inhibit the...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , |
|---|---|
| Format: | Patent |
| Sprache: | eng ; fre ; ger |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | ZHANG, Shaohua XU, Kexin WANG, Fei LUO, Tongchuan HUO, Yongxu WU, Xiaoquan FAN, Lei CHEN, Yuanwei LI, Xinghai |
| description | An EP300/CBP inhibitor; specifically provided is a compound as shown in formula I, or a deuterated product thereof, or a salt thereof, or a conformational isomer thereof, or a crystal form thereof, or a solvate thereof. The compound is highly selective for EP300/CBP, and can effectively inhibit the activity of EP300/CBP; in addition, the compound has an excellent inhibitory effect on various tumor cells including prostate cancer cells, leukemia cells, breast cancer cells and multiple myeloma cells. The compound has broad application prospects in the preparation of an EP300/CBP inhibitor, and drugs for preventing and/or treating tumors, myeloid hematopoietic stem/progenitor cells malignant disease, and regulating regulatory T cells. |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_EP4043458A1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>EP4043458A1</sourcerecordid><originalsourceid>FETCH-epo_espacenet_EP4043458A13</originalsourceid><addsrcrecordid>eNrjZBB2DTA2MNB3dgpQ8PTz8HTyDPEP4mFgTUvMKU7lhdLcDApuriHOHrqpBfnxqcUFicmpeakl8a4BJgYmxiamFo6GxkQoAQD6Vx2O</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>EP300/CBP INHIBITOR</title><source>esp@cenet</source><creator>ZHANG, Shaohua ; XU, Kexin ; WANG, Fei ; LUO, Tongchuan ; HUO, Yongxu ; WU, Xiaoquan ; FAN, Lei ; CHEN, Yuanwei ; LI, Xinghai</creator><creatorcontrib>ZHANG, Shaohua ; XU, Kexin ; WANG, Fei ; LUO, Tongchuan ; HUO, Yongxu ; WU, Xiaoquan ; FAN, Lei ; CHEN, Yuanwei ; LI, Xinghai</creatorcontrib><description>An EP300/CBP inhibitor; specifically provided is a compound as shown in formula I, or a deuterated product thereof, or a salt thereof, or a conformational isomer thereof, or a crystal form thereof, or a solvate thereof. The compound is highly selective for EP300/CBP, and can effectively inhibit the activity of EP300/CBP; in addition, the compound has an excellent inhibitory effect on various tumor cells including prostate cancer cells, leukemia cells, breast cancer cells and multiple myeloma cells. The compound has broad application prospects in the preparation of an EP300/CBP inhibitor, and drugs for preventing and/or treating tumors, myeloid hematopoietic stem/progenitor cells malignant disease, and regulating regulatory T cells.</description><language>eng ; fre ; ger</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2022</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220817&DB=EPODOC&CC=EP&NR=4043458A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220817&DB=EPODOC&CC=EP&NR=4043458A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>ZHANG, Shaohua</creatorcontrib><creatorcontrib>XU, Kexin</creatorcontrib><creatorcontrib>WANG, Fei</creatorcontrib><creatorcontrib>LUO, Tongchuan</creatorcontrib><creatorcontrib>HUO, Yongxu</creatorcontrib><creatorcontrib>WU, Xiaoquan</creatorcontrib><creatorcontrib>FAN, Lei</creatorcontrib><creatorcontrib>CHEN, Yuanwei</creatorcontrib><creatorcontrib>LI, Xinghai</creatorcontrib><title>EP300/CBP INHIBITOR</title><description>An EP300/CBP inhibitor; specifically provided is a compound as shown in formula I, or a deuterated product thereof, or a salt thereof, or a conformational isomer thereof, or a crystal form thereof, or a solvate thereof. The compound is highly selective for EP300/CBP, and can effectively inhibit the activity of EP300/CBP; in addition, the compound has an excellent inhibitory effect on various tumor cells including prostate cancer cells, leukemia cells, breast cancer cells and multiple myeloma cells. The compound has broad application prospects in the preparation of an EP300/CBP inhibitor, and drugs for preventing and/or treating tumors, myeloid hematopoietic stem/progenitor cells malignant disease, and regulating regulatory T cells.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2022</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZBB2DTA2MNB3dgpQ8PTz8HTyDPEP4mFgTUvMKU7lhdLcDApuriHOHrqpBfnxqcUFicmpeakl8a4BJgYmxiamFo6GxkQoAQD6Vx2O</recordid><startdate>20220817</startdate><enddate>20220817</enddate><creator>ZHANG, Shaohua</creator><creator>XU, Kexin</creator><creator>WANG, Fei</creator><creator>LUO, Tongchuan</creator><creator>HUO, Yongxu</creator><creator>WU, Xiaoquan</creator><creator>FAN, Lei</creator><creator>CHEN, Yuanwei</creator><creator>LI, Xinghai</creator><scope>EVB</scope></search><sort><creationdate>20220817</creationdate><title>EP300/CBP INHIBITOR</title><author>ZHANG, Shaohua ; XU, Kexin ; WANG, Fei ; LUO, Tongchuan ; HUO, Yongxu ; WU, Xiaoquan ; FAN, Lei ; CHEN, Yuanwei ; LI, Xinghai</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_EP4043458A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre ; ger</language><creationdate>2022</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>ZHANG, Shaohua</creatorcontrib><creatorcontrib>XU, Kexin</creatorcontrib><creatorcontrib>WANG, Fei</creatorcontrib><creatorcontrib>LUO, Tongchuan</creatorcontrib><creatorcontrib>HUO, Yongxu</creatorcontrib><creatorcontrib>WU, Xiaoquan</creatorcontrib><creatorcontrib>FAN, Lei</creatorcontrib><creatorcontrib>CHEN, Yuanwei</creatorcontrib><creatorcontrib>LI, Xinghai</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>ZHANG, Shaohua</au><au>XU, Kexin</au><au>WANG, Fei</au><au>LUO, Tongchuan</au><au>HUO, Yongxu</au><au>WU, Xiaoquan</au><au>FAN, Lei</au><au>CHEN, Yuanwei</au><au>LI, Xinghai</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>EP300/CBP INHIBITOR</title><date>2022-08-17</date><risdate>2022</risdate><abstract>An EP300/CBP inhibitor; specifically provided is a compound as shown in formula I, or a deuterated product thereof, or a salt thereof, or a conformational isomer thereof, or a crystal form thereof, or a solvate thereof. The compound is highly selective for EP300/CBP, and can effectively inhibit the activity of EP300/CBP; in addition, the compound has an excellent inhibitory effect on various tumor cells including prostate cancer cells, leukemia cells, breast cancer cells and multiple myeloma cells. The compound has broad application prospects in the preparation of an EP300/CBP inhibitor, and drugs for preventing and/or treating tumors, myeloid hematopoietic stem/progenitor cells malignant disease, and regulating regulatory T cells.</abstract><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | eng ; fre ; ger |
| recordid | cdi_epo_espacenet_EP4043458A1 |
| source | esp@cenet |
| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | EP300/CBP INHIBITOR |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-27T18%3A00%3A19IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=ZHANG,%20Shaohua&rft.date=2022-08-17&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EEP4043458A1%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |