NOVEL SUBSTITUTED 6,7-DIHYDRO-5H-BENZO[7]ANNULENE COMPOUNDS, PROCESSES FOR THEIR PREPARATION AND THERAPEUTIC USES THEREOF
The present invention relates to a compound of the formula (i) wherein Ar represents a phenyl or a 6-membered heteroaryl group, R1 and R2 represent independently a hydrogen atom or a deuterium atom, R3 represents (1) a -COR4 group, (2) a -BOR5OR6 group, (3) a -X-Z group, (4) a (C1-C6)alkyl group or...
Gespeichert in:
| Hauptverfasser: | , , , , , , , |
|---|---|
| Format: | Patent |
| Sprache: | eng ; fre ; ger |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | BOISNARD, Sabine TABART, Michel NICOLAI, Eric EL-AHMAD, Youssef VIVET, Bertrand FETT, Eykmar TERRIER, Corinne HALLEY, Frank |
| description | The present invention relates to a compound of the formula (i) wherein Ar represents a phenyl or a 6-membered heteroaryl group, R1 and R2 represent independently a hydrogen atom or a deuterium atom, R3 represents (1) a -COR4 group, (2) a -BOR5OR6 group, (3) a -X-Z group, (4) a (C1-C6)alkyl group or a (C1-C6)alkenyl group, (5) a -X-S(O)n(R7)p(R8)q group, (6) a halogen atom, a -NH2 group or a -CN group, (7) a -O-R11 group, (8) a -NH-COR9 group, (9) a -C(═NH)NHOH group, (10) a -NH-C(NH)-R9′ group, or (11) a -NHCOCOOR12 group or a -NHCOCONR12′R12″ group, X represents abond, a -NH- group, a -CONH- group or a -CO- group, Z represents a 4 or 5-membered cycloalkyl, a 4 or 5-membered heterocylcloalkyl group, a 4 or 5-membered heteroaryl group or a phenyl group or a pharmaceutically acceptable salt thereof. The present invention further relates to a medicament comprising said compound of formula (I) and to said compound of formula (I) for use as an inhibitor and degrader of estrogen receptors. |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_EP4037768A1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>EP4037768A1</sourcerecordid><originalsourceid>FETCH-epo_espacenet_EP4037768A13</originalsourceid><addsrcrecordid>eNqNyk0KwjAQQOFuXIh6hzlAC0rVuE2TKQnUTMiPoCKlSFyJFurG22vBA7h68PGm2dvQARvwsfJBhxhQwjZnhdTqKB0VG1VUaE50ZhduTGzQIAjaW4pG-hysI4Heo4eaHASF2n0NLXc8aDLAjRzVcYsxaAFxXEdAqufZ5Nbdh7T4dZZBjUGoIvXPNg19d02P9GrRrpclY9sdX5V_LB-nvzpm</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>NOVEL SUBSTITUTED 6,7-DIHYDRO-5H-BENZO[7]ANNULENE COMPOUNDS, PROCESSES FOR THEIR PREPARATION AND THERAPEUTIC USES THEREOF</title><source>esp@cenet</source><creator>BOISNARD, Sabine ; TABART, Michel ; NICOLAI, Eric ; EL-AHMAD, Youssef ; VIVET, Bertrand ; FETT, Eykmar ; TERRIER, Corinne ; HALLEY, Frank</creator><creatorcontrib>BOISNARD, Sabine ; TABART, Michel ; NICOLAI, Eric ; EL-AHMAD, Youssef ; VIVET, Bertrand ; FETT, Eykmar ; TERRIER, Corinne ; HALLEY, Frank</creatorcontrib><description>The present invention relates to a compound of the formula (i) wherein Ar represents a phenyl or a 6-membered heteroaryl group, R1 and R2 represent independently a hydrogen atom or a deuterium atom, R3 represents (1) a -COR4 group, (2) a -BOR5OR6 group, (3) a -X-Z group, (4) a (C1-C6)alkyl group or a (C1-C6)alkenyl group, (5) a -X-S(O)n(R7)p(R8)q group, (6) a halogen atom, a -NH2 group or a -CN group, (7) a -O-R11 group, (8) a -NH-COR9 group, (9) a -C(═NH)NHOH group, (10) a -NH-C(NH)-R9′ group, or (11) a -NHCOCOOR12 group or a -NHCOCONR12′R12″ group, X represents abond, a -NH- group, a -CONH- group or a -CO- group, Z represents a 4 or 5-membered cycloalkyl, a 4 or 5-membered heterocylcloalkyl group, a 4 or 5-membered heteroaryl group or a phenyl group or a pharmaceutically acceptable salt thereof. The present invention further relates to a medicament comprising said compound of formula (I) and to said compound of formula (I) for use as an inhibitor and degrader of estrogen receptors.</description><language>eng ; fre ; ger</language><subject>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM ; CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2022</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220810&DB=EPODOC&CC=EP&NR=4037768A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,777,882,25545,76296</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220810&DB=EPODOC&CC=EP&NR=4037768A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>BOISNARD, Sabine</creatorcontrib><creatorcontrib>TABART, Michel</creatorcontrib><creatorcontrib>NICOLAI, Eric</creatorcontrib><creatorcontrib>EL-AHMAD, Youssef</creatorcontrib><creatorcontrib>VIVET, Bertrand</creatorcontrib><creatorcontrib>FETT, Eykmar</creatorcontrib><creatorcontrib>TERRIER, Corinne</creatorcontrib><creatorcontrib>HALLEY, Frank</creatorcontrib><title>NOVEL SUBSTITUTED 6,7-DIHYDRO-5H-BENZO[7]ANNULENE COMPOUNDS, PROCESSES FOR THEIR PREPARATION AND THERAPEUTIC USES THEREOF</title><description>The present invention relates to a compound of the formula (i) wherein Ar represents a phenyl or a 6-membered heteroaryl group, R1 and R2 represent independently a hydrogen atom or a deuterium atom, R3 represents (1) a -COR4 group, (2) a -BOR5OR6 group, (3) a -X-Z group, (4) a (C1-C6)alkyl group or a (C1-C6)alkenyl group, (5) a -X-S(O)n(R7)p(R8)q group, (6) a halogen atom, a -NH2 group or a -CN group, (7) a -O-R11 group, (8) a -NH-COR9 group, (9) a -C(═NH)NHOH group, (10) a -NH-C(NH)-R9′ group, or (11) a -NHCOCOOR12 group or a -NHCOCONR12′R12″ group, X represents abond, a -NH- group, a -CONH- group or a -CO- group, Z represents a 4 or 5-membered cycloalkyl, a 4 or 5-membered heterocylcloalkyl group, a 4 or 5-membered heteroaryl group or a phenyl group or a pharmaceutically acceptable salt thereof. The present invention further relates to a medicament comprising said compound of formula (I) and to said compound of formula (I) for use as an inhibitor and degrader of estrogen receptors.</description><subject>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM</subject><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2022</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNyk0KwjAQQOFuXIh6hzlAC0rVuE2TKQnUTMiPoCKlSFyJFurG22vBA7h68PGm2dvQARvwsfJBhxhQwjZnhdTqKB0VG1VUaE50ZhduTGzQIAjaW4pG-hysI4Heo4eaHASF2n0NLXc8aDLAjRzVcYsxaAFxXEdAqufZ5Nbdh7T4dZZBjUGoIvXPNg19d02P9GrRrpclY9sdX5V_LB-nvzpm</recordid><startdate>20220810</startdate><enddate>20220810</enddate><creator>BOISNARD, Sabine</creator><creator>TABART, Michel</creator><creator>NICOLAI, Eric</creator><creator>EL-AHMAD, Youssef</creator><creator>VIVET, Bertrand</creator><creator>FETT, Eykmar</creator><creator>TERRIER, Corinne</creator><creator>HALLEY, Frank</creator><scope>EVB</scope></search><sort><creationdate>20220810</creationdate><title>NOVEL SUBSTITUTED 6,7-DIHYDRO-5H-BENZO[7]ANNULENE COMPOUNDS, PROCESSES FOR THEIR PREPARATION AND THERAPEUTIC USES THEREOF</title><author>BOISNARD, Sabine ; TABART, Michel ; NICOLAI, Eric ; EL-AHMAD, Youssef ; VIVET, Bertrand ; FETT, Eykmar ; TERRIER, Corinne ; HALLEY, Frank</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_EP4037768A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre ; ger</language><creationdate>2022</creationdate><topic>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM</topic><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>BOISNARD, Sabine</creatorcontrib><creatorcontrib>TABART, Michel</creatorcontrib><creatorcontrib>NICOLAI, Eric</creatorcontrib><creatorcontrib>EL-AHMAD, Youssef</creatorcontrib><creatorcontrib>VIVET, Bertrand</creatorcontrib><creatorcontrib>FETT, Eykmar</creatorcontrib><creatorcontrib>TERRIER, Corinne</creatorcontrib><creatorcontrib>HALLEY, Frank</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>BOISNARD, Sabine</au><au>TABART, Michel</au><au>NICOLAI, Eric</au><au>EL-AHMAD, Youssef</au><au>VIVET, Bertrand</au><au>FETT, Eykmar</au><au>TERRIER, Corinne</au><au>HALLEY, Frank</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>NOVEL SUBSTITUTED 6,7-DIHYDRO-5H-BENZO[7]ANNULENE COMPOUNDS, PROCESSES FOR THEIR PREPARATION AND THERAPEUTIC USES THEREOF</title><date>2022-08-10</date><risdate>2022</risdate><abstract>The present invention relates to a compound of the formula (i) wherein Ar represents a phenyl or a 6-membered heteroaryl group, R1 and R2 represent independently a hydrogen atom or a deuterium atom, R3 represents (1) a -COR4 group, (2) a -BOR5OR6 group, (3) a -X-Z group, (4) a (C1-C6)alkyl group or a (C1-C6)alkenyl group, (5) a -X-S(O)n(R7)p(R8)q group, (6) a halogen atom, a -NH2 group or a -CN group, (7) a -O-R11 group, (8) a -NH-COR9 group, (9) a -C(═NH)NHOH group, (10) a -NH-C(NH)-R9′ group, or (11) a -NHCOCOOR12 group or a -NHCOCONR12′R12″ group, X represents abond, a -NH- group, a -CONH- group or a -CO- group, Z represents a 4 or 5-membered cycloalkyl, a 4 or 5-membered heterocylcloalkyl group, a 4 or 5-membered heteroaryl group or a phenyl group or a pharmaceutically acceptable salt thereof. The present invention further relates to a medicament comprising said compound of formula (I) and to said compound of formula (I) for use as an inhibitor and degrader of estrogen receptors.</abstract><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | eng ; fre ; ger |
| recordid | cdi_epo_espacenet_EP4037768A1 |
| source | esp@cenet |
| subjects | ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | NOVEL SUBSTITUTED 6,7-DIHYDRO-5H-BENZO[7]ANNULENE COMPOUNDS, PROCESSES FOR THEIR PREPARATION AND THERAPEUTIC USES THEREOF |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-17T13%3A56%3A09IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=BOISNARD,%20Sabine&rft.date=2022-08-10&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EEP4037768A1%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |