METHODS OF PRODUCING AN ANTI-ALPHA4BETA7 ANTIBODY

METHODS OF PRODUCING AN ANTI-ALPHA4BETA7 ANTIBODY

Provided herein are methods for purifying an anti-α4β7 integrin antibody, such as vedolizumab, from a liquid solution, e.g., from a mammalian cell culture clarified harvest. The invention relates, inter alia, to purification methods for controlling the amount of product-related substances and/or pro...

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Hauptverfasser: MILLER, Amy, HILO, Nicole, AMELI, Debra, CARTER, Susan R, PALEY, Olga, BHATIA, Paras, KUNDU, Amitava, PARKS, George, DOLAN, Michael E
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Sprache:eng ; fre ; ger
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CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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creator MILLER, Amy
HILO, Nicole
AMELI, Debra
CARTER, Susan R
PALEY, Olga
BHATIA, Paras
KUNDU, Amitava
PARKS, George
DOLAN, Michael E
description Provided herein are methods for purifying an anti-α4β7 integrin antibody, such as vedolizumab, from a liquid solution, e.g., from a mammalian cell culture clarified harvest. The invention relates, inter alia, to purification methods for controlling the amount of product-related substances and/or process-related impurities present in purified preparations of an anti-α4β7 integrin antibody, or antigen-binding fragment thereof, e.g., vedolizumab. Compositions comprising an anti-α4β7 antibody, and uses thereof to treat a disorder, are also provided.
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subjects CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
title METHODS OF PRODUCING AN ANTI-ALPHA4BETA7 ANTIBODY
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