PROXIMITY-BASED LABELING SYSTEMS AND APPLICATIONS THEREOF
In one aspect, compositions and methods are described herein for providing a microenvironment mapping platform operable to selectively identify various features, including protein-protein interactions on cellular membranes. In some embodiments, a composition comprises a catalyst, and a protein label...
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| creator | OAKLEY, James REYES-ROBLES, Tamara MACMILLAN, David, W.C FADEYI, Olugbeminiyi, O PARKER, Dann, Leroy OSLUND, Rob, C GERI, Jacob RODRIGUEZ-RIVERA, Frances, Paola McCARVER, Stefan WANG, Tao |
| description | In one aspect, compositions and methods are described herein for providing a microenvironment mapping platform operable to selectively identify various features, including protein-protein interactions on cellular membranes. In some embodiments, a composition comprises a catalyst, and a protein labeling agent, wherein the catalyst activates the protein labeling agent to a reactive intermediate. The catalyst, in some embodiments, can have electronic structure for permitting energy transfer to the protein labeling agent to form the reactive intermediate. The reactive intermediate reacts or crosslinks with a protein or other biomolecule within the diffusion radius of the reactive intermediate. |
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In some embodiments, a composition comprises a catalyst, and a protein labeling agent, wherein the catalyst activates the protein labeling agent to a reactive intermediate. The catalyst, in some embodiments, can have electronic structure for permitting energy transfer to the protein labeling agent to form the reactive intermediate. The reactive intermediate reacts or crosslinks with a protein or other biomolecule within the diffusion radius of the reactive intermediate.</description><language>eng ; fre ; ger</language><subject>ADHESIVES ; ALLOYS ; CASTING ; CHEMISTRY ; DYES ; FERROUS OR NON-FERROUS ALLOYS ; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES ; MAKING METALLIC POWDER ; MANUFACTURE OF ARTICLES FROM METALLIC POWDER ; MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FORELSEWHERE ; MEASURING ; METALLURGY ; MISCELLANEOUS APPLICATIONS OF MATERIALS ; MISCELLANEOUS COMPOSITIONS ; NATURAL RESINS ; ORGANIC CHEMISTRY ; PAINTS ; PEPTIDES ; PERFORMING OPERATIONS ; PHYSICS ; POLISHES ; POWDER METALLURGY ; TESTING ; TRANSPORTING ; TREATMENT OF ALLOYS OR NON-FERROUS METALS ; WORKING METALLIC POWDER</subject><creationdate>2024</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20241120&DB=EPODOC&CC=EP&NR=3980205B1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20241120&DB=EPODOC&CC=EP&NR=3980205B1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>OAKLEY, James</creatorcontrib><creatorcontrib>REYES-ROBLES, Tamara</creatorcontrib><creatorcontrib>MACMILLAN, David, W.C</creatorcontrib><creatorcontrib>FADEYI, Olugbeminiyi, O</creatorcontrib><creatorcontrib>PARKER, Dann, Leroy</creatorcontrib><creatorcontrib>OSLUND, Rob, C</creatorcontrib><creatorcontrib>GERI, Jacob</creatorcontrib><creatorcontrib>RODRIGUEZ-RIVERA, Frances, Paola</creatorcontrib><creatorcontrib>McCARVER, Stefan</creatorcontrib><creatorcontrib>WANG, Tao</creatorcontrib><title>PROXIMITY-BASED LABELING SYSTEMS AND APPLICATIONS THEREOF</title><description>In one aspect, compositions and methods are described herein for providing a microenvironment mapping platform operable to selectively identify various features, including protein-protein interactions on cellular membranes. 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In some embodiments, a composition comprises a catalyst, and a protein labeling agent, wherein the catalyst activates the protein labeling agent to a reactive intermediate. The catalyst, in some embodiments, can have electronic structure for permitting energy transfer to the protein labeling agent to form the reactive intermediate. The reactive intermediate reacts or crosslinks with a protein or other biomolecule within the diffusion radius of the reactive intermediate.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | ADHESIVES ALLOYS CASTING CHEMISTRY DYES FERROUS OR NON-FERROUS ALLOYS INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MAKING METALLIC POWDER MANUFACTURE OF ARTICLES FROM METALLIC POWDER MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FORELSEWHERE MEASURING METALLURGY MISCELLANEOUS APPLICATIONS OF MATERIALS MISCELLANEOUS COMPOSITIONS NATURAL RESINS ORGANIC CHEMISTRY PAINTS PEPTIDES PERFORMING OPERATIONS PHYSICS POLISHES POWDER METALLURGY TESTING TRANSPORTING TREATMENT OF ALLOYS OR NON-FERROUS METALS WORKING METALLIC POWDER |
| title | PROXIMITY-BASED LABELING SYSTEMS AND APPLICATIONS THEREOF |
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