BROMOCRIPTINE FORMULATIONS

A dosage form comprising: bromocriptine mesylate and one or more excipients; wherein the dosage form provides for absorption of a substantial amount of bromocriptine through the gastric and/or intestinal mucosa when administered to a subject; wherein the bromocriptine has a Dv90 of about 15 µm or lo...

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Bibliographische Detailangaben
Hauptverfasser: CINOTTA, Anthony, BOWE, Craig Michael, STEARNS, Paul Clark, WESTON, Laura Jean
Format: Patent
Sprache:eng ; fre ; ger
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Zusammenfassung:A dosage form comprising: bromocriptine mesylate and one or more excipients; wherein the dosage form provides for absorption of a substantial amount of bromocriptine through the gastric and/or intestinal mucosa when administered to a subject; wherein the bromocriptine has a Dv90 of about 15 µm or lower; wherein the bromocriptine has a particle size distribution with a span of about 2 or lower; and wherein the dosage form provides a dissolution profile, when tested in USP Apparatus Type 2 Paddle Method at 50 rpm in 500 mL of 0.1 N hydrochloric acid at about 37° C, wherein at least about 80% of the bromocriptine has been released at about 30 minutes; wherein the dosage form is in the form of a solid dosage form.