ANTI-PD-L1/VEGF BIFUNCTIONAL ANTIBODY AND USE THEREOF

The present invention provides an anti-PD-L1/VEGF bispecific antibody and a use thereof. Specifically, the present invention provides a bifunctional antibody, comprising: (a) anti-PD-Ll antibody or element; and (b) an anti-VEGF antibody or element linked to the anti-PD-L1 antibody or element. The bi...

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Hauptverfasser: CHEN, Shi, ZHANG, Lei, YU, Ling, ZHANG, Fengxue, CAI, Mingqing, ZHU, Xiangyang
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creator CHEN, Shi
ZHANG, Lei
YU, Ling
ZHANG, Fengxue
CAI, Mingqing
ZHU, Xiangyang
description The present invention provides an anti-PD-L1/VEGF bispecific antibody and a use thereof. Specifically, the present invention provides a bifunctional antibody, comprising: (a) anti-PD-Ll antibody or element; and (b) an anti-VEGF antibody or element linked to the anti-PD-L1 antibody or element. The bifunctional antibody of the present invention can simultaneously bind to VEGF and PD-L1, thereby exerting a therapeutic effect on VEGF and PD-L1-positive tumor cells (especially malignant tumor cells).
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Specifically, the present invention provides a bifunctional antibody, comprising: (a) anti-PD-Ll antibody or element; and (b) an anti-VEGF antibody or element linked to the anti-PD-L1 antibody or element. 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subjects BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
HUMAN NECESSITIES
HYGIENE
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PEPTIDES
PHYSICS
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SPIRITS
TESTING
VINEGAR
WINE
title ANTI-PD-L1/VEGF BIFUNCTIONAL ANTIBODY AND USE THEREOF
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