NOVEL SYNTHETIC OPTIONS TOWARDS THE MANUFACTURE OF (6R,10S)-10- {4-[5-CHLORO-2-(4-CHLORO-1H-1,2,3-TRIAZOL-1-YL)PHENYL]-6-OXO-1(6H)- PYRIMIDINYL}- 1-(DIFLUOROMETHYL)-6-METHYL-1,4,7,8,9,10-HEXAHYDRO-11,15 -(METHENO)PYRAZOLO [4,3-B] [1,7] DIAZACYCLOTETRADECIN-5(6H)-ONE

NOVEL SYNTHETIC OPTIONS TOWARDS THE MANUFACTURE OF (6R,10S)-10- {4-[5-CHLORO-2-(4-CHLORO-1H-1,2,3-TRIAZOL-1-YL)PHENYL]-6-OXO-1(6H)- PYRIMIDINYL}- 1-(DIFLUOROMETHYL)-6-METHYL-1,4,7,8,9,10-HEXAHYDRO-11,15 -(METHENO)PYRAZOLO [4,3-B] [1,7] DIAZACYCLOTETRADECIN-5(6H)-ONE

Highly efficient methods are provided for preparing key intermediates in the synthesis of Compound (I), which are broadly applicable and can provide selected components having a variety of substituents groups.

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Hauptverfasser: KOLOTUCHIN, Sergei, WAGSCHAL, Simon Albert, SINGH, Amarjit, BEN HAIM, Cyril, ZHENG, Bin, YUAN, Changxia, BROGGINI, Diego Fernando Domenico, CUNIERE, Nicolas, XIAO, Yi, CHERNICHENKO, Kostiantyn, MUKHERJEE, Subha, WEI, Carolyn S, FAN, Yu, LEMAIRE, Sébastien François Emmanuel, SIMMONS, Eric M, CAO, Duy Chi Trung
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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creator KOLOTUCHIN, Sergei
WAGSCHAL, Simon Albert
SINGH, Amarjit
BEN HAIM, Cyril
ZHENG, Bin
YUAN, Changxia
BROGGINI, Diego Fernando Domenico
CUNIERE, Nicolas
XIAO, Yi
CHERNICHENKO, Kostiantyn
MUKHERJEE, Subha
WEI, Carolyn S
FAN, Yu
LEMAIRE, Sébastien François Emmanuel
SIMMONS, Eric M
CAO, Duy Chi Trung
description Highly efficient methods are provided for preparing key intermediates in the synthesis of Compound (I), which are broadly applicable and can provide selected components having a variety of substituents groups.
format Patent
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
title NOVEL SYNTHETIC OPTIONS TOWARDS THE MANUFACTURE OF (6R,10S)-10- {4-[5-CHLORO-2-(4-CHLORO-1H-1,2,3-TRIAZOL-1-YL)PHENYL]-6-OXO-1(6H)- PYRIMIDINYL}- 1-(DIFLUOROMETHYL)-6-METHYL-1,4,7,8,9,10-HEXAHYDRO-11,15 -(METHENO)PYRAZOLO [4,3-B] [1,7] DIAZACYCLOTETRADECIN-5(6H)-ONE
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