BIODEGRADABLE POLYMER MICROPARTICLE CONTAINING STEROID-BASED DRUG AND PREPARATION METHOD THEREFOR

The present invention relates to biodegradable polymer microparticles containing a steroid-based drug and a preparation method therefor. Biodegradable polymer microparticles containing a steroid-based drug are prepared by a preparation method wherein: the steroid-based drug and a biodegradable polyester-based polymer are dissolved in a suitable organic solvent; the solution is sprayed into a low-temperature hydrocarbon solution to form frozen microparticles; and then the same microparticles are added to a low-temperature aqueous salt solution to dissolve the organic solvent contained in the microparticles. The biodegradable polymer microparticles containing a steroid-based drug or a sex hormone drug, which is a steroid-based drug, are found to have excellent biocompatibility, biodegradability, porosity, and mechanical strength and release the steroid-based drug or the sex hormone drug, which is a steroid-based drug, in a sustained manner for a long period of time, whereby the biodegradable polymer microparticles containing a steroid-based drug or a sex hormone drug, which is a steroid-based drug, according to the present invention are expected to develop a formulation that can treat a symptom or disease attributed to the reduction or depletion of a steroid or a sex hormone, which is a kind of steroid, by release the drug uniformly and continuously for a long period of time.