METHOD FOR PRODUCING PEPTIDE COMPOUND

METHOD FOR PRODUCING PEPTIDE COMPOUND

The present invention is to provide a method for producing a peptide containing an N-alkylamino acid, which comprises the following Steps (1) to (3). Step (1): a step of mixing an N-terminal protected amino acid or an N-terminal protected peptide with a carboxylic acid halide or a halogenated alkyl...

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Hauptverfasser: KOBAYASHI, Yutaka, NAGAYA, Akihiro, TAKEUCHI, Hisayuki, ASAKA, Yukio, TAGURI, Tomonori, NEMOTO, Yoshitaka, MASUYA, Keiichi, KURASAKI, Haruaki, CARY, Douglas Robert, HANDA, Michiharu, MATSUDA, Ayumu
Format: Patent
Sprache:eng ; fre ; ger
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ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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creator KOBAYASHI, Yutaka
NAGAYA, Akihiro
TAKEUCHI, Hisayuki
ASAKA, Yukio
TAGURI, Tomonori
NEMOTO, Yoshitaka
MASUYA, Keiichi
KURASAKI, Haruaki
CARY, Douglas Robert
HANDA, Michiharu
MATSUDA, Ayumu
description The present invention is to provide a method for producing a peptide containing an N-alkylamino acid, which comprises the following Steps (1) to (3). Step (1): a step of mixing an N-terminal protected amino acid or an N-terminal protected peptide with a carboxylic acid halide or a halogenated alkyl formate; Step (2): a step of mixing an amino acid or a peptide in which the N-terminal and the C-terminal are not protected with a trialkylsilylating agent; and Step (3): a step of mixing the product obtained in Step (1) with the product obtained in Step (2).
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subjects ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
title METHOD FOR PRODUCING PEPTIDE COMPOUND
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