METHOD FOR PRODUCING PEPTIDE COMPOUND

The present invention is to provide a method for producing a peptide containing an N-alkylamino acid, which comprises the following Steps (1) to (3). Step (1): a step of mixing an N-terminal protected amino acid or an N-terminal protected peptide with a carboxylic acid halide or a halogenated alkyl...

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Bibliographische Detailangaben
Hauptverfasser:	KOBAYASHI, Yutaka, NAGAYA, Akihiro, TAKEUCHI, Hisayuki, ASAKA, Yukio, TAGURI, Tomonori, NEMOTO, Yoshitaka, MASUYA, Keiichi, KURASAKI, Haruaki, CARY, Douglas Robert, HANDA, Michiharu, MATSUDA, Ayumu
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY METALLURGY ORGANIC CHEMISTRY PEPTIDES
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Beschreibung
Zusammenfassung:	The present invention is to provide a method for producing a peptide containing an N-alkylamino acid, which comprises the following Steps (1) to (3). Step (1): a step of mixing an N-terminal protected amino acid or an N-terminal protected peptide with a carboxylic acid halide or a halogenated alkyl formate; Step (2): a step of mixing an amino acid or a peptide in which the N-terminal and the C-terminal are not protected with a trialkylsilylating agent; and Step (3): a step of mixing the product obtained in Step (1) with the product obtained in Step (2).